Evaluation of bone marrow reticulin in patients with chronic immune thrombocytopenia treated with eltrombopag: Data from the EXTEND study

被引：48

作者：

Brynes, Russell K. ^{[1
]}

Orazi, Attilio ^{[2
]}

Theodore, Dickens ^{[3
]}

Burgess, Paul ^{[4
]}

Bailey, Christine K. ^{[5
]}

Thein, Maung M. ^{[1
]}

Bakshi, Kalpana K. ^{[5
]}

机构：

[1] Univ So Calif, Keck Sch Med, Dept Pathol, Los Angeles, CA 90033 USA

[2] Cornell Univ, Weill Med Coll, Dept Pathol, New York, NY 10021 USA

[3] GlaxoSmithKline, Res Triangle Pk, NC USA

[4] GlaxoSmithKline, Stockley Pk, England

[5] GlaxoSmithKline, Collegeville, PA USA

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 2015年 / 90卷 / 07期

关键词：

LONG-TERM; EFFICACY; ROMIPLOSTIM; FIBROSIS; PURPURA; SAFETY;

D O I：

10.1002/ajh.24011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thrombopoietin receptor agonists, which raise platelet counts in patients with chronic immune thrombocytopenia, may be associated with increases in bone marrow (BM) reticulin. Patients with chronic immune thrombocytopenia participating in the Eltrombopag Extended Dosing (EXTEND) study underwent BM biopsies to identify clinically relevant BM fibrosis-related increases. Specimens were centrally reviewed by 2 hematopathologists. Two hundred thirty-two biopsy specimens were collected from 117 patients treated for 5.5 years. Moderate to marked reticulin fibrosis was found in 2 patients. After withdrawing from the study, the biopsy of 1 patient reverted to normal. There were no other pathologic changes identified among on-treatment specimens, and no pattern of abnormal reticulin deposition associated with eltrombopag treatment was evident. Am. J. Hematol. 90:598-601, 2015. (c) 2015 Wiley Periodicals, Inc.

引用

页码：598 / 601

页数：4

共 15 条

[1] Successful treatment of early secondary myelofibrosis in SLE with IVIG [J].

Aharon, A ;

Levy, Y ;

BarDayan, Y ;

Afek, A ;

ZandmanGoddard, G ;

Skurnik, Y ;

Fabrizzi, F ;

Shoenfeld, Y .

LUPUS, 1997, 6 (04) :408-411

[2] Thrombopoietin receptor agonist therapy in primary immune thrombocytopenia is associated with bone marrow hypercellularity and mild reticulin fibrosis but not other stromal abnormalities [J].

Boiocchi, Leonardo ;

Orazi, Attilio ;

Ghanima, Waleed ;

Arabadjief, Melissa ;

Bussel, James B. ;

Geyer, Julia Turbiner .

MODERN PATHOLOGY, 2012, 25 (01) :65-74

[3] Evaluation Of The Effects Of Long-Term Treatment With Eltrombopag On Bone Marrow In Patients With Chronic Immune Thrombocytopenia (ITP) - Data From The EXTEND Study [J].

Brynes, Russell K. ;

Orazi, Attilio ;

Bakshi, Kalpana ;

Bailey, Christine K. ;

Chan, Geoffrey W. .

BLOOD, 2013, 122 (21)

[4] Safety and efficacy of long-term treatment with romiplostim in thrombocytopenic patients with chronic ITP [J].

Bussel, James B. ;

Kuter, David J. ;

Pullarkat, Vinod ;

Lyons, Roger M. ;

Guo, Matthew ;

Nichol, Janet L. .

BLOOD, 2009, 113 (10) :2161-2171

[5] Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist [J].

Erickson-Miller, CL ;

DeLorme, E ;

Tian, SS ;

Hopson, CB ;

Stark, K ;

Giampa, L ;

Valoret, EI ;

Duffy, KJ ;

Luengo, JL ;

Rosen, J ;

Miller, SG ;

Dillon, SB ;

Lamb, P .

EXPERIMENTAL HEMATOLOGY, 2005, 33 (01) :85-93

[6] Bone marrow reticulin and collagen content in patients with adult chronic immune thrombocytopenic purpura: A Danish nationwide study [J].

Ettrup, Marianne Schmidt ;

Jensen, Annette Ostergaard ;

Engebjerg, Malene Cramer ;

Farkas, Dora Kormendine ;

Norgaard, Mette ;

Cha, Steven ;

Zhao, Sean ;

Johansen, Preben ;

Sorensen, Henrik Toft .

AMERICAN JOURNAL OF HEMATOLOGY, 2010, 85 (12) :930-934

[7]

FRISCH B, 1982, Haematologia, V15, P245

[8] Bone marrow fibrosis in 66 patients with immune thrombocytopenia treated with thrombopoietin-receptor agonists: a single-center, long-term follow-up [J].

Ghanima, Waleed ;

Geyer, Julia Turbiner ;

Lee, Christina S. ;

Boiocchi, Leonardo ;

Imahiyerobo, Allison A. ;

Orazi, Attilio ;

Bussel, James B. .

HAEMATOLOGICA, 2014, 99 (05) :937-944

[9] Fibroproliferative activity in patients with immune thrombocytopenia (ITP) treated with thrombopoietic agents [J].

Ghanima, Waleed ;

Junker, Peter ;

Hasselbalch, Hans Carl ;

Boiocchi, Leonardo ;

Geyer, Julia T. ;

Feng, Xingmin ;

Gudbrandsdottir, Sif ;

Orazi, Attilio ;

Bussel, James B. .

BRITISH JOURNAL OF HAEMATOLOGY, 2011, 155 (02) :248-255

[10] Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura:: a double-blind randomised controlled trial [J].

Kuter, David J. ;

Bussel, James B. ;

Lyons, Roger M. ;

Pullarkat, Vinod ;

Gernsheimer, Terry B. ;

Senecal, Francis M. ;

Aledort, Louis M. ;

George, James N. ;

Kessler, Craig M. ;

Sanz, Miguel A. ;

Liebman, Howard A. ;

Slovick, Frank T. ;

de Wolf, J. Th M. ;

Bourgeois, Emmanuelle ;

Guthrie, Troy H., Jr. ;

Newland, Adrian ;

Wasser, Jeffrey S. ;

Hamburg, Solomon I. ;

Grande, Carlos ;

Lefrere, Francois ;

Lichtin, Alan Eli ;

Tarantino, Michael D. ;

Terebelo, Howard R. ;

Viallard, Jean-Francois ;

Cuevas, Francis J. ;

Go, Ronald S. ;

Henry, David H. ;

Redner, Robert L. ;

Rice, Lawrence ;

Schipperus, Martin R. ;

Guo, D. Matthew ;

Nichol, Janet L. .

LANCET, 2008, 371 (9610) :395-403

← 1 2 →