Rearranged ent-kauranoid glycosides from the fruits of Xanthium strumarium and their antiproliferative activity

被引：15

作者：

Jiang, Hai ^{[1
,2
,3
]}

Ma, Guo-Xu ^{[1
,2
]}

Yang, Liu ^{[3
]}

Xing, Xu-Dong ^{[3
]}

Yan, Mei-Ling ^{[3
]}

Zhang, Yan-Yan ^{[3
]}

Wang, Qiu-Hong ^{[3
,4
]}

Kuang, Hai-Xue ^{[3
]}

Xu, Xu-Dong ^{[1
,2
]}

机构：

[1] Minist Educ, Key Lab Bioact Subst & Resources Utilizat Chinese, Inst Med Plant Dev, Peking Union Med Coll, Beijing 100193, Peoples R China

[2] Chinese Acad Med Sci, Beijing 100193, Peoples R China

[3] Heilongjiang Univ Chinese Med, Key Lab Chinese MateriaMed, Minist Educ, Harbin 150040, Peoples R China

[4] Guangdong Pharmaceut Univ, Guangzhou 528458, Guangdong, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2016年 / 18卷

关键词：

X; strumarium; ent-kauranoid diterpenes; Cytotoxic activity; SESQUITERPENE LACTONES; AERIAL PARTS; DITERPENOIDS; SIBIRICUM;

D O I：

10.1016/j.phytol.2016.10.007

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new ent-kauranoid glycosides, fructusnoids A-C (1-3) were isolated from the fruits of Xanthium strumarium. Their structures were elucidated by extensive spectroscopic methods, including NMR, MS, and HRESIMS data. Compounds 1-2 are novel examples of rearranged ent-kauranoid diterpenes with missing C-18/19 carbons. All the compounds were evaluated for their antiproliferative activity in vitro against three human cancer cell lines, and compound 3 showed selective cytotoxic activity against the AGS cancer cell line with an IC50 value of 7.6 mu M. (C) 2016 Phytochemical Society of Europe. Published by Elsevier Ltd. All rights reserved.

引用

页码：192 / 196

页数：5

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