The role of tumor-associated macrophages in oral squamous cell carcinoma

被引：21
作者：
Xue, Yiwen [1 ,2 ]
Song, Xiao [1 ,2 ]
Fan, Siyu [1 ,2 ]
Deng, Runzhi [1 ]
机构：
[1] Nanjing Univ, Nanjing Stomatol Hosp, Dept Oral & Maxillofacial Surg, Med Sch, Nanjing, Jiangsu, Peoples R China
[2] Nanjing Univ, Nanjing Stomatol Hosp, Cent Lab Stomatol, Med Sch, Nanjing, Jiangsu, Peoples R China
来源：
FRONTIERS IN PHYSIOLOGY | 2022年 / 13卷
关键词：
TAMs; OSCC; invasion and metastasis; angiogenesis; immunosuppression; GROWTH-FACTOR; CANCER; METASTASIS; INVASION; POLARIZATION; PATHWAY; HEAD; PROMOTE; MICROENVIRONMENT; INHIBITION;
D O I：
10.3389/fphys.2022.959747
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Oral squamous cell carcinoma (OSCC) is a common head and neck cancer with a high recurrence rate and a low 5-year survival rate. Tumor-associated macrophages (TAMs) are important immune cells in the tumor microenvironment, which play an important role in the progression of many tumors. This article reviews the origin, and the role of TAMs in the invasion, metastasis, angiogenesis and immunosuppression of OSCC. Therapeutic strategies targeting TAMs are also discussed in hopes of providing new ideas for the treatment of OSCC.
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页数：8
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