Vaccination Against SARS-CoV-2 Is Associated With a Lower Viral Load and Likelihood of Systemic Symptoms

被引:18
作者
Bramante, Carolyn T. [1 ]
Proper, Jennifer L. [2 ]
Boulware, David R. [3 ]
Karger, Amy B. [4 ]
Murray, Thomas [2 ]
Rao, Via [1 ]
Hagen, Aubrey [1 ]
Tignanelli, Christopher J. [5 ]
Puskarich, Michael [6 ]
Cohen, Ken [7 ]
Liebovitz, David M. [8 ]
Klatt, Nichole R. [5 ]
Broedlow, Courtney [5 ]
Hartman, Katrina M. [1 ]
Nicklas, Jacinda [9 ]
Ibrahim, Sherehan [1 ]
Zaman, Adnin [9 ]
Saveraid, Hanna [1 ]
Belani, Hrishikesh [10 ]
Ingraham, Nicholas [11 ]
Christensen, Grace [1 ]
Siegel, Lianne [2 ]
Sherwood, Nancy E. [12 ]
Fricton, Regina [8 ]
Lee, Sam [8 ]
Odde, David J. [13 ]
Buse, John B. [14 ]
Huling, Jared D. [2 ]
机构
[1] Univ Minnesota, Gen Internal Med, Med Sch, Minneapolis, MN 55454 USA
[2] Univ Minnesota, Biostat, Sch Publ Hlth, Minneapolis, MN 55454 USA
[3] Univ Minnesota, Infect Dis & Int Med, Med Sch, Minneapolis, MN 55454 USA
[4] Univ Minnesota, Lab Med & Pathol, Med Sch, Minneapolis, MN 55454 USA
[5] Univ Minnesota, Surg, Med Sch, Minneapolis, MN 55454 USA
[6] Univ Minnesota, Dept Emergency Med, Med Sch, Minneapolis, MN 55454 USA
[7] Optum, Optum Ctr Res & Innovat, Minnetonka, MN USA
[8] Northwestern Univ, Gen Internal Med, Feinberg Sch Med, Chicago, IL 60611 USA
[9] Univ Colorado, Sch Med, Gen Internal Med, Aurora, CO USA
[10] Olive View UCLA Med Ctr, Primary Care, Los Angeles, CA USA
[11] Univ Minnesota, Med Sch, Pulm Allergy Crit Care & Sleep Med, Minneapolis, MN 55454 USA
[12] Univ Minnesota, Epidemiol, Sch Publ Hlth, Minneapolis, MN 55454 USA
[13] Univ Minnesota, Biomed Engn, Minneapolis, MN 55454 USA
[14] Univ N Carolina, Sch Med, Endocrinol, Chapel Hill, NC 27515 USA
基金
美国国家卫生研究院;
关键词
SARS-CoV-2; symptoms; vaccines; viral load;
D O I
10.1093/ofid/ofac066
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background Data conflict on whether vaccination decreases severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load. The objective of this analysis was to compare baseline viral load and symptoms between vaccinated and unvaccinated adults enrolled in a randomized trial of outpatient coronavirus disease 2019 (COVID-19) treatment. Methods Baseline data from the first 433 sequential participants enrolling into the COVID-OUT trial were analyzed. Adults aged 30-85 with a body mass index (BMI) >= 25 kg/m(2) were eligible within 3 days of a positive SARS-CoV-2 test and <7 days of symptoms. Log(10) polymerase chain reaction viral loads were normalized to human RNase P by vaccination status, by time from vaccination, and by symptoms. Results Two hundred seventy-four participants with known vaccination status contributed optional nasal swabs for viral load measurement: median age, 46 years; median (interquartile range) BMI 31.2 (27.4-36.4) kg/m(2). Overall, 159 (58%) were women, and 217 (80%) were White. The mean relative log(10) viral load for those vaccinated <6 months from the date of enrollment was 0.11 (95% CI, -0.48 to 0.71), which was significantly lower than the unvaccinated group (P = .01). Those vaccinated >= 6 months before enrollment did not differ from the unvaccinated with respect to viral load (mean, 0.99; 95% CI, -0.41 to 2.40; P = .85). The vaccinated group had fewer moderate/severe symptoms of subjective fever, chills, myalgias, nausea, and diarrhea (all P < .05). Conclusions These data suggest that vaccination within 6 months of infection is associated with a lower viral load, and vaccination was associated with a lower likelihood of having systemic symptoms.
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页数:9
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