Relationships between barley consumption and gut microbiome characteristics in a healthy Japanese population: a cross-sectional study

被引：15

作者：

Matsuoka, Tsubasa ^{[1
,2
,3
,4
]}

Hosomi, Koji ^{[3
,4
]}

Park, Jonguk ^{[5
,6
]}

Goto, Yuka ^{[1
,3
,4
]}

Nishimura, Mao ^{[1
,3
,4
]}

Maruyama, Satoko ^{[1
,3
,4
]}

Murakami, Haruka ^{[7
,8
]}

Konishi, Kana ^{[7
,8
]}

Miyachi, Motohiko ^{[7
,8
]}

Kawashima, Hitoshi ^{[5
,6
]}

Mizuguchi, Kenji ^{[5
,6
,9
]}

Kobayashi, Toshiki ^{[1
]}

Yokomichi, Hiroshi ^{[2
]}

Kunisawa, Jun ^{[3
,4
,10
,11
,12
,13
,14
,15
]}

Yamagata, Zentaro ^{[2
]}

机构：

[1] Hakubaku Co Ltd, Res & Dev Dept, Chuo Ku, 4629 Nishihanawa, Chuo, Yamanashi 4093843, Japan

[2] Univ Yamanashi, Sch Med, Dept Hlth Sci, Chuo Ku, 1110 Shimokato, Chuo, Yamanashi 4093898, Japan

[3] Natl Inst Biomed Innovat, Lab Vaccine Mat, Ctr Vaccine & Adjuvant Res, 7-6-8 Saito Asagi, Ibaraki, Osaka 5670085, Japan

[4] Natl Inst Hlth & Nutr, Lab Vaccine Mat, Ctr Vaccine & Adjuvant Res, 7-6-8 Saito Asagi, Ibaraki, Osaka 5670085, Japan

[5] Natl Inst Biomed Innovat, Artificial Intelligence Ctr Hlth & Biomed Res, 7-6-8 Saito Asagi, Ibaraki, Osaka 5670085, Japan

[6] Natl Inst Hlth & Nutr, Artificial Intelligence Ctr Hlth & Biomed Res, 7-6-8 Saito Asagi, Ibaraki, Osaka 5670085, Japan

[7] Natl Inst Biomed Innovat, Dept Phys Act Res, Shinjuku Ku, 1-23-1 Toyama, Tokyo 1628636, Japan

[8] Natl Inst Hlth & Nutr, Dept Phys Act Res, Shinjuku Ku, 1-23-1 Toyama, Tokyo 1628636, Japan

[9] Osaka Univ, Inst Prot Res, Lab Computat Biol, 3-2 Yamadaoka, Suita, Osaka 5650871, Japan

[10] Kobe Univ, Dept Microbiol & Immunol, Grad Sch Med, Chuo Ku, 7-5-1 Kusunoki Cho, Kobe, Hyogo 6500017, Japan

[11] Osaka Univ, Grad Sch Pharmaceut Sci, Grad Sch Med, 1-1 Yamadaoka, Suita, Osaka 5650871, Japan

[12] Osaka Univ, Grad Sch Dent, 1-1 Yamadaoka, Suita, Osaka 5650871, Japan

[13] Univ Tokyo, Dept Microbiol & Immunol, Minato Ku, 4-6-1 Shirokanedai, Tokyo 1088639, Japan

[14] Univ Tokyo, Int Res & Dev Ctr, Minato Ku, 4-6-1 Shirokanedai, Tokyo 1088639, Japan

[15] Waseda Univ, Res Org Nano & Life Innovat, Shinjuku Ku, 513 Waseda Tsurumaki Cho, Tokyo 1620041, Japan

来源：

BMC NUTRITION | 2022年 / 8卷 / 01期

关键词：

Barley; Beta-glucan; Microbiome; Bifidobacterium; Butyricicoccus; DIETARY FIBER;

D O I：

10.1186/s40795-022-00500-3

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background Barley contains abundant soluble beta-glucan fibers, which have established health benefits. In addition, the health benefits conferred by the gut bacteria have attracted considerable interest. However, few studies have focused on the barley consumption and gut bacteria of the Japanese population. In this study, we aimed to identify the relationship between the barley consumption and gut bacteria composition of the Japanese population. Methods In total, 236 participants were recruited in Japan, and 94 participants with no complications of diabetes, hypertension, or dyslipidemia were selected for the study. We analyzed fecal samples from the participants, their medical check-up results, and responses to questionnaires about dietary habits. The participants were grouped according to their median barley consumption. Then, we assessed the relative abundance of 50 genera. Characteristic bacteria were evaluated for their relationship with barley consumption by multiple regression analysis, adjusted for disease and dietary habits, in all participants. We also analyzed the networks and clustering of the 20 selected genera. Results According to the comparison between barley groups, Bifidobacterium, Butyricicoccus, Collinsella, Ruminococcus 2, and Dialister were characteristic candidate bacterias of the group that consumed large amounts of barley (P < 0.05). The relationship between barley consumption and Bifidobacterium remained after adjusting for disease and dietary habits, and that of Butyricicoccus remained after adjusting for disease. Furthermore, network and cluster analyses revealed that barley consumption was directly correlated with Bifidobacterium and Butyricicoccus. Conclusions Barley consumption generates changes in the intestinal bacteria of the Japanese population. We found that Bifidobacterium and Butyricicoccus abundance was positively associated with barley consumption.

引用

页数：10

共 23 条

[1] Enterotypes of the human gut microbiome [J].

Arumugam, Manimozhiyan ;

Raes, Jeroen ;

Pelletier, Eric ;

Le Paslier, Denis ;

Yamada, Takuji ;

Mende, Daniel R. ;

Fernandes, Gabriel R. ;

Tap, Julien ;

Bruls, Thomas ;

Batto, Jean-Michel ;

Bertalan, Marcelo ;

Borruel, Natalia ;

Casellas, Francesc ;

Fernandez, Leyden ;

Gautier, Laurent ;

Hansen, Torben ;

Hattori, Masahira ;

Hayashi, Tetsuya ;

Kleerebezem, Michiel ;

Kurokawa, Ken ;

Leclerc, Marion ;

Levenez, Florence ;

Manichanh, Chaysavanh ;

Nielsen, H. Bjorn ;

Nielsen, Trine ;

Pons, Nicolas ;

Poulain, Julie ;

Qin, Junjie ;

Sicheritz-Ponten, Thomas ;

Tims, Sebastian ;

Torrents, David ;

Ugarte, Edgardo ;

Zoetendal, Erwin G. ;

Wang, Jun ;

Guarner, Francisco ;

Pedersen, Oluf ;

de Vos, Willem M. ;

Brunak, Soren ;

Dore, Joel ;

Weissenbach, Jean ;

Ehrlich, S. Dusko ;

Bork, Peer .

NATURE, 2011, 473 (7346) :174-180

[2] QIIME allows analysis of high-throughput community sequencing data [J].

Caporaso, J. Gregory ;

Kuczynski, Justin ;

Stombaugh, Jesse ;

Bittinger, Kyle ;

Bushman, Frederic D. ;

Costello, Elizabeth K. ;

Fierer, Noah ;

Pena, Antonio Gonzalez ;

Goodrich, Julia K. ;

Gordon, Jeffrey I. ;

Huttley, Gavin A. ;

Kelley, Scott T. ;

Knights, Dan ;

Koenig, Jeremy E. ;

Ley, Ruth E. ;

Lozupone, Catherine A. ;

McDonald, Daniel ;

Muegge, Brian D. ;

Pirrung, Meg ;

Reeder, Jens ;

Sevinsky, Joel R. ;

Tumbaugh, Peter J. ;

Walters, William A. ;

Widmann, Jeremy ;

Yatsunenko, Tanya ;

Zaneveld, Jesse ;

Knight, Rob .

NATURE METHODS, 2010, 7 (05) :335-336

[3]

Casella G., 2006, DESIGN, V102, P618, DOI [10.1007/978-0-387-35434-7, DOI 10.1007/978-0-387-35434-7]

[4] Butyricicoccus pullicaecorum in inflammatory bowel disease [J].

Eeckhaut, Venessa ;

Machiels, Kathleen ;

Perrier, Clementine ;

Romero, Carlos ;

Maes, Sofie ;

Flahou, Bram ;

Steppe, Marjan ;

Haesebrouck, Freddy ;

Sas, Benedikt ;

Ducatelle, Richard ;

Vermeire, Severine ;

Van Immerseel, Filip .

GUT, 2013, 62 (12) :1745-1752

[5] Effects of whole-grain wheat, rye, and lignan supplementation on cardiometabolic risk factors in men with metabolic syndrome: a randomized crossover trial [J].

Eriksen, Anne K. ;

Brunius, Carl ;

Mazidi, Mohsen ;

Hellstrom, Per M. ;

Riserus, Ulf ;

Iversen, Kia N. ;

Fristedt, Rikard ;

Sun, Li ;

Huang, Yi ;

Norskov, Natalja P. ;

Knudsen, Knud Erik B. ;

Kyro, Cecilie ;

Olsen, Anja ;

Tjonneland, Anne ;

Dicksved, Johan ;

Landberg, Rikard .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2020, 111 (04) :864-876

[6] Method for preparing DNA from feces in guanidine thiocyanate solution affects 16S rRNA-based profiling of human microbiota diversity [J].

Hosomi, Koji ;

Ohno, Harumi ;

Murakami, Haruka ;

Natsume-Kitatani, Yayoi ;

Tanisawa, Kumpei ;

Hirata, Soichiro ;

Suzuki, Hidehiko ;

Nagatake, Takahiro ;

Nishino, Tomomi ;

Mizuguchi, Kenji ;

Miyachi, Motohiko ;

Kunisawa, Jun .

SCIENTIFIC REPORTS, 2017, 7

[7] Application of ggplot2 to Pharmacometric Graphics [J].

Ito, K. ;

Murphy, D. .

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 2013, 2 (10)

[8]

Kobayashi T., 2013, J JAPANESE ASS DIET, V17, P35

[9] Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella [J].

Kovatcheva-Datchary, Petia ;

Nilsson, Anne ;

Akrami, Rozita ;

Lee, Ying Shiuan ;

De Vadder, Filipe ;

Arora, Tulika ;

Hallen, Anna ;

Martens, Eric ;

Bjorck, Inger ;

Backhed, Fredrik .

CELL METABOLISM, 2015, 22 (06) :971-982

[10] Carbohydrate digestion in humans from a β-glucan-enriched barley is reduced [J].

Lifschitz, CH ;

Grusak, MA ;

Butte, NF .

JOURNAL OF NUTRITION, 2002, 132 (09) :2593-2596

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