Design, synthesis and anticancer activity of novel nopinone-based thiosemicarbazone derivatives

被引：69

作者：

Wang, Yunyun ^{[1
]}

Gu, Wen ^{[1
,5
]}

Shari, Yu ^{[2
,3
]}

Liu, Fei ^{[2
,3
]}

Ku, Xu ^{[1
,5
]}

Yang, Yiqin ^{[4
]}

Zhang, Qiandian ^{[1
]}

Zhang, Yan ^{[1
]}

Kuang, Hongbo ^{[1
]}

Wang, Zhonglong ^{[1
]}

Wang, Shifa ^{[1
,4
]}

机构：

[1] Nanjing Forestry Univ, Coll Chem Engn, Nanjing 210037, Jiangsu, Peoples R China

[2] Inst Bot, Nanjing 210014, Jiangsu, Peoples R China

[3] Chinese Acad Sci, Nanjing Bot Garden, Sun Yat Sen, Nanjing 210014, Peoples R China

[4] Nanjing Forestry Univ, Inst Light Ind Sci & Engn, Nanjing 210037, Jiangsu, Peoples R China

[5] Jiangsu Key Lab Biomass Based Green Fuels & Chem, Nanjing 210037, Jiangsu, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2017年 / 27卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Nopinone; Thiosemicarbazone; Anticancer; Apoptosis; BETA-PINENE; BIOLOGICAL EVALUATION; ANTITUMOR-ACTIVITY; IRON CHELATORS; ALPHA-PINENE; INHIBITION; COMPLEXES; PATHWAY; 3-AP;

D O I：

10.1016/j.bmcl.2017.04.024

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of new nopinone-based thiosemicarbazone derivatives were designed and synthesized as potent anticancer agents. All these compounds were identified by H-1 NMR, C-13 NMR, HR-MS spectra analyses. In the in vitro anticancer activity, most derivatives showed considerable cytotoxic activity against three human cancer cell lines (MDA-MB-231, SMMC-7721 and Hela). Among them, compound 4i exhibited most potent antitumor activity against three cancer cell lines with the IC50 values of 2.79 +/- 0.38, 2.64 +/- 0.17 and 3.64 +/- 0.13 mu M, respectively. Furthermore, the cell cycle analysis indicated that compound 4i caused cell cycle arrest of MDA-MB-231 cells at G2/M phase. The Annexin V-FITC/7-AAD dual staining assay also revealed that compound 4i induced the early apoptosis of MDA-MB-231 cells. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：2360 / 2363

页数：4

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