Innovation is considered a key driver for economic growth and is usually studied in the form of systems, with the regional level being arguably the most important. Despite constantly improving technological infrastructure, the human-related aspects of innovation are still the most important part of the innovation process. The human factor in innovation essentially consists of three components: (1) human capital, which refers to education, knowledge, and skills; (2) social capital, which refers to the strength of social links and social coherence; and (3) psychological capital, which refers to peoples' values, attitudes, and behaviors. The research findings confirmed this view and showed which specific indicators of the three types of capital had a significant impact on innovation output. A new, extended regional innovation scoreboard emphasizing the human factor, is proposed. Also, based on the findings, and bearing in mind current EU innovation policies, a number of measures are proposed in order to suggest "more human" smart specialization policies in order to increase innovation in European regions and coherence between them.