Association between composite scores of domain-specific cognitive functions and regional patterns of atrophy and functional connectivity in the Alzheimer's disease spectrum

被引：23

作者：

Amaefule, Chimezie O. ^{[1
]}

Dyrba, Martin ^{[1
]}

Wolfsgruber, Steffen ^{[2
,3
]}

Polcher, Alexandra ^{[2
]}

Schneider, Anja ^{[2
,3
]}

Fliessbach, Klaus ^{[2
,3
]}

Spottke, Annika ^{[2
,14
]}

Meiberth, Dix ^{[2
,15
]}

Preis, Lukas ^{[4
,5
]}

Peters, Oliver ^{[4
,5
]}

Incesoy, Enise I. ^{[4
,5
]}

Spruth, Eike J. ^{[4
,5
]}

Priller, Josef ^{[4
,5
]}

Altenstein, Slawek ^{[4
,5
]}

Bartels, Claudia ^{[7
]}

Wiltfang, Jens ^{[6
,7
,8
]}

Janowitz, Daniel ^{[10
]}

Buerger, Katharina ^{[9
,10
]}

Laske, Christoph ^{[11
,12
,13
]}

Munk, Matthias ^{[12
,13
]}

Rudolph, Janna ^{[2
]}

Glanz, Wenzel ^{[18
]}

Dobisch, Laura ^{[18
]}

Haynes, John D. ^{[21
]}

Dechent, Peter ^{[23
]}

Ertl-Wagner, Birgit ^{[24
]}

Scheffler, Klaus ^{[22
]}

Kilimann, Ingo ^{[1
,17
]}

Duezel, Emrah ^{[18
,19
]}

Metzger, Coraline D. ^{[18
,19
,20
]}

Wagner, Michael ^{[2
,3
]}

Jessen, Frank ^{[2
,15
,16
]}

Teipel, Stefan J. ^{[1
,17
]}

机构：

[1] German Ctr Neurodegenerat Dis DZNE, Gehlsheimer Str 20, D-18147 Rostock, Germany

[2] German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

[3] Univ Hosp, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany

[4] German Ctr Neurodegenerat Dis DZNE, Berlin, Germany

[5] Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, Campus Benjamin Franklin, Berlin, Germany

[6] German Ctr Neurodegenerat Dis DZNE, Gottingen, Germany

[7] Univ Med Ctr Goettingen UMG, Dept Psychiat & Psychotherapy, Gottingen, Germany

[8] Univ Aveiro, Inst Biomed iBiMED, Dept Med Sci, Neurosci & Signaling Grp, Aveiro, Portugal

[9] German Ctr Neurodegenerat Dis DZNE, Munich, Germany

[10] Ludwig Maximilians Univ Munchen, Univ Hosp, Inst Stroke & Dementia Res ISD, Munich, Germany

[11] German Ctr Neurodegenerat Dis DZNE, Tubingen, Germany

[12] Univ Tubingen, Hertie Inst Clin Brain Res, Sect Dementia Res, Tubingen, Germany

[13] Univ Tubingen, Dept Psychiat & Psychotherapy, Tubingen, Germany

[14] Univ Hosp Bonn, Dept Neurol, Bonn, Germany

[15] Univ Cologne, Dept Psychiat, Cologne, Germany

[16] Univ Cologne, Excellence Cluster Cellular Stress Responses Agin, Cologne, Germany

[17] Rostock Univ, Dept Psychosomat Med, Med Ctr, Rostock, Germany

[18] German Ctr Neurodegenerat Dis DZNE, Magdeburg, Germany

[19] Otto von Guericke Univ, Inst Cognit Neurol & Dementia Res IKND, Magdeburg, Germany

[20] Otto von Guericke Univ, Dept Psychiat & Psychotherapy, Magdeburg, Germany

[21] Charite, Bernstein Ctr Computat Neurosci, Berlin, Germany

[22] Univ Tubingen, Dept Biomed Magnet Resonance, Tubingen, Germany

[23] Georg August Univ Goettingen, MR Res Neurol & Psychiat, Gottingen, Germany

[24] Ludwig Maximilians Univ Munchen, Inst Clin Radiol, Munich, Germany

来源：

NEUROIMAGE-CLINICAL | 2021年 / 29卷

关键词：

Visuo-spatial cognitive deficits; Resting-state functional connectivity; Alzheimer's disease spectrum; Cognitive domain score; Cortical atrophy; Multicenter cohort;

D O I：

10.1016/j.nicl.2020.102533

中图分类号：

R445 [影像诊断学];

学科分类号：

100207 ;

摘要：

Background: Cognitive decline has been found to be associated with gray matter atrophy and disruption of functional neural networks in Alzheimer's disease (AD) in structural and functional imaging (fMRI) studies. Most previous studies have used single test scores of cognitive performance among monocentric cohorts. However, cognitive domain composite scores could be more reliable than single test scores due to the reduction of measurement error. Adopting a multicentric resting state fMRI (rs-fMRI) and cognitive domain approach, we provide a comprehensive description of the structural and functional correlates of the key cognitive domains of AD. Method: We analyzed MRI, rs-fMRI and cognitive domain score data of 490 participants from an interim baseline release of the multicenter DELCODE study cohort, including 54 people with AD, 86 with Mild Cognitive Impairment (MCI), 175 with Subjective Cognitive Decline (SCD), and 175 Healthy Controls (HC) in the AD-spectrum. Resulting cognitive domain composite scores (executive, visuo-spatial, memory, working memory and language) from the DELCODE neuropsychological battery (DELCODE-NP), were previously derived using confirmatory factor analysis. Statistical analyses examined the differences between diagnostic groups, and the association of composite scores with regional atrophy and network-specific functional connectivity among the patient subgroup of SCD, MCI and AD. Result: Cognitive performance, atrophy patterns and functional connectivity significantly differed between diagnostic groups in the AD-spectrum. Regional gray matter atrophy was positively associated with visuospatial and other cognitive impairments among the patient subgroup in the AD-spectrum. Except for the visual network, patterns of network-specific resting-state functional connectivity were positively associated with distinct cognitive impairments among the patient subgroup in the AD-spectrum. Conclusion: Consistent associations between cognitive domain scores and both regional atrophy and networkspecific functional connectivity (except for the visual network), support the utility of a multicentric and cognitive domain approach towards explicating the relationship between imaging markers and cognition in the AD-spectrum.

引用

页数：11

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