Therapy of community-acquired acute bacterial meningitis: the clock is running

被引：18

作者：

Klein, M. ^{[1
]}

Pfister, H. W. ^{[1
]}

Leib, S. L. ^{[2
]}

Koedel, U. ^{[1
]}

机构：

[1] Univ Munich, Klinikum Grosshadern, Dept Neurol, D-83533 Munich, Germany

[2] Univ Bern, Inst Infect Dis, CH-3010 Bern, Switzerland

来源：

EXPERT OPINION ON PHARMACOTHERAPY | 2009年 / 10卷 / 16期

关键词：

antibiotic therapy; bacterial; CNS infection; meningitis; Neisseria meningitidis; Streptococcus pneumoniae; RESISTANT STREPTOCOCCUS-PNEUMONIAE; SERUM PROCALCITONIN LEVELS; PNEUMOCOCCAL MENINGITIS; CEREBROSPINAL-FLUID; ANTIMICROBIAL SUSCEPTIBILITY; CLINICAL-FEATURES; DEXAMETHASONE TREATMENT; PARENTERAL PENICILLIN; STAPHYLOCOCCUS-AUREUS; INTRACRANIAL-PRESSURE;

D O I：

10.1517/14656560903277210

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Despite antibiotic therapy and supportive intensive medical care, bacterial meningitis remains a disease with high mortality and morbidity. Rapid recognition of symptoms is crucial to direct physicians quickly towards appropriate diagnostic measures and, initially, empiric antibiotic therapy. it has become evident that time from arrival at the hospital to application of the first dose of antibiotics is a crucial independent factor that influences outcome. Here, we review the clinical and laboratory presentation of community-acquired bacterial meningitis and the antibiotic regiments that are currently recommended for its treatment; future therapeutic options are also discussed. Finally, suggestions for the approach to a patient with suspected bacterial meningitis are presented.

引用

页码：2609 / 2623

页数：15

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