Synthetic RNA circuits

被引：49
作者：
Davidson, Eric A. [1 ]
Ellington, Andrew D. [1 ]
机构：
[1] Univ Texas, Inst Cell & Mol Biol, Dept Chem & Biochem, Austin, TX 78712 USA
来源：
NATURE CHEMICAL BIOLOGY | 2007年 / 3卷 / 01期
关键词：
D O I：
10.1038/nchembio846
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Natural and engineered RNA 'parts' can perform a variety of functions, including hybridizing to targets, binding ligands and undergoing programmed conformational changes, and catalyzing reactions. These RNA parts can in turn be assembled into synthetic genetic circuits that regulate gene expression by acting either in cis or in trans on mRNAs. As more parts are discovered and engineered, it should be increasingly possible to create synthetic RNA circuits that are able to carry out complex logical operations in cells, either superimposed on or autonomous to extant gene regulation.
引用
收藏
页码：23 / 28
页数：6
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