Potential Molecular Mechanisms of the Anti-cancer Activity of Vitamin D

被引：29

作者：

Skrajnowska, Dorota ^{[1
]}

Bobrowska-Korczak, Barbara ^{[1
]}

机构：

[1] Med Univ Warsaw, Dept Bromatol, Banacha 1, PL-02097 Warsaw, Poland

来源：

ANTICANCER RESEARCH | 2019年 / 39卷 / 07期

关键词：

Vitamin D; nVDR receptor; antitumor effect; review; TRANSITIONAL-CELL CARCINOMA; D-RECEPTOR EXPRESSION; MUTANT P53 GAIN; SKIN-CANCER; 1,25-DIHYDROXYVITAMIN D-3; ANALOG EB1089; 1-ALPHA; 25-DIHYDROXYVITAMIN D-3; TUMOR-METASTASIS; GENE-EXPRESSION; BREAST-CANCER;

D O I：

10.21873/anticanres.13478

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Vitamin D, or more precisely its active metabolite calcitriol (1,25-(OH)(2)D-3), plays a fundamental role in bone metabolism and differentiation as well as in intestinal absorption of calcium and regulation of calcium-phosphate metabolism. Recent decades have brought about the discovery of the role of calcitriol in processes regulating cell differentiation, proliferation, angiogenesis and apoptosis. This creates the potential for numerous therapeutic applications of vitamin D in diseases associated with autoaggressive immune responses or in cancer. This study presents selected issues regarding current knowledge of the anti-cancer mechanisms of vitamin D.

引用

收藏

页码：3353 / 3363

页数：11

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