Activated Ras signaling significantly enhances reovirus replication and spread

被引：23
作者：
Shmulevitz, M. [1 ]
Marcato, P. [1 ]
Lee, P. W. K. [1 ]
机构：
[1] Dalhousie Univ, Dept Microbiol & Immunol, Halifax, NS, Canada
来源：
CANCER GENE THERAPY | 2010年 / 17卷 / 01期
关键词：
COLORECTAL TUMOR-CELLS; ONCOLYSIS; APOPTOSIS; INFECTION; T3D;
D O I：
10.1038/cgt.2009.46
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
引用
收藏
页码：69 / 70
页数：2
相关论文
共 9 条
[1]   Proteolytic disassembly is a critical determinant for reovirus oncolysis [J].
Alain, Tommy ;
Kim, Tom S. Y. ;
Lun, XueQing ;
Liacini, Adelhamid ;
Schiff, Leslie A. ;
Senger, Donna L. ;
Forsyth, Peter A. .
MOLECULAR THERAPY, 2007, 15 (08) :1512-1521
[2]   Ras transformation mediates reovirus oncolysis by enhancing virus uncoating, particle infectivity, and apoptosis-dependent release [J].
Marcato, Paola ;
Shmulevitz, Maya ;
Pan, Da ;
Stoltz, Don ;
Lee, Patrick W. K. .
MOLECULAR THERAPY, 2007, 15 (08) :1522-1530
[3]   Correlation between interferon sensitivity of reovirus isolates and ability to discriminate between normal and Ras-transformed cells [J].
Rudd, P ;
Lemay, G .
JOURNAL OF GENERAL VIROLOGY, 2005, 86 :1489-1497
[4]   Sensitization to apoptosis underlies KrasD12-dependent oncolysis of murine C26 colorectal carcinoma cells by reovirus T3D [J].
Smakman, N ;
van den Wollenberg, DJM ;
Rinkes, IHMB ;
Hoeben, RC ;
Kranenburg, O .
JOURNAL OF VIROLOGY, 2005, 79 (23) :14981-14985
[5]   KRASD13 promotes apoptosis of human colorectal tumor cells by ReovirusT3D and oxaliplatin but not by tumor necrosis factor-related apoptosis-inducing ligand [J].
Smakman, Niels ;
van den Wollenberg, Diana J. M. ;
Elias, Sjoerd G. ;
Sasazuki, Takehiko ;
Shirasawa, Senji ;
Hoeben, Rob C. ;
Rinkes, Inne H. M. Borel ;
Kranenblug, Onno .
CANCER RESEARCH, 2006, 66 (10) :5403-5408
[6]  
SONG L, 2008, CANC GENE THER
[7]   The v-erbB oncogene confers enhanced cellular susceptibility to reovirus infection [J].
Strong, JE ;
Lee, PWK .
JOURNAL OF VIROLOGY, 1996, 70 (01) :612-616
[8]   The molecular basis of viral oncolysis: usurpation of the Ras signaling pathway by reovirus [J].
Strong, JE ;
Coffey, MC ;
Tang, D ;
Sabinin, P ;
Lee, PWK .
EMBO JOURNAL, 1998, 17 (12) :3351-3362
[9]   Transient infection of freshly isolated human colorectal tumor cells by reovirus T3D intermediate subviral particles [J].
van Houdt, W. J. ;
Smakman, N. ;
van den Wollenberg, D. J. M. ;
Emmink, B. L. ;
Veenendaal, L. M. ;
van Diest, P. J. ;
Hoeben, R. C. ;
Rinkes, I. H. M. Borel ;
Kranenburg, O. .
CANCER GENE THERAPY, 2008, 15 (05) :284-292
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