Fluorescent probes for nitric oxide and hydrogen peroxide in cell signaling

被引：153
作者：
Miller, Evan W. [1 ]
Chang, Christopher J. [1 ]
机构：
[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 2007年 / 11卷 / 06期
关键词：
D O I：
10.1016/j.cbpa.2007.09.018
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nitric oxide (NO) and hydrogen peroxide (H2O2) have emerged as essential small molecules for cellular signal transduction owing largely to their ability to mediate oxidative posttranslational modifications (PTMs). Inventing new ways to track these small, diffusible, and reactive species with spatial and temporal resolution is a key challenge in elucidating their chemistry in living systems. Recent progress in the development of fluorescent probes that respond selectively to NO and H2O2 produced at cell signaling levels offers a promising approach to interrogating their physiological production, accumulation, trafficking, and function.
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页码：620 / 625
页数：6
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