Effect of glyprolines on norepinephrine tone of isolated rat aortic rings

被引：5

作者：

Bakaeva, ZV ^{[1
]}

Badmaeva, KE ^{[1
]}

Sergeev, IY ^{[1
]}

Samonina, GE ^{[1
]}

机构：

[1] Moscow MV Lomonosov State Univ, Fac Biol, Dept Human & Anim Physiol, Moscow 117234, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2003年 / 135卷 / 04期

关键词：

glyprolines; endothelium; blood flow;

D O I：

10.1023/A:1024696327745

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Glyprolines, short proline-containing peptides (Pro-Gly-Pro, Pro-Gly, and Gly-Pro) in concentrations of 10(-8)-10(-4) M decreased norepinephrine tone of the isolated rat aortic rings. The vasodilatory effect of Pro-Gly-Pro and Pro-Gly was associated with NO release from endotheliocytes, while Gly-Pro directly affected vascular smooth muscle cells.

引用

页码：334 / 336

页数：3

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