No association between the KCNH1, KCNJ10 and KCNN3 genes and schizophrenia in the Han Chinese population

被引：2

作者：

Shen, Qi ^{[2
,3
]}

Zhang, Jing ^{[2
,3
]}

Wang, Yang ^{[2
,3
]}

Liu, Baocheng ^{[2
,3
]}

Li, Xingwang ^{[1
,2
,3
]}

Zhao, Qingzhu ^{[2
,3
]}

Chen, Shiqing ^{[2
,3
]}

Ji, Jue ^{[2
,3
]}

Yang, Fengping ^{[2
,3
]}

Wan, Chunling ^{[2
,3
]}

Gao, Linghan ^{[2
,3
]}

Xu, Yifeng ^{[4
]}

Feng, Guoyin ^{[4
]}

He, Lin ^{[1
,2
,3
]}

He, Guang ^{[2
,3
]}

机构：

[1] Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R China

[2] Shanghai Jiao Tong Univ, Bio X Ctr, Key Lab Genet Dev & Neuropsychiat Disorders, Minist Educ, Shanghai 200030, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China

[4] Shanghai Inst Mental Hlth, Shanghai 200030, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2011年 / 487卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Han Chinese population; Potassium channels; Schizophrenia; POTASSIUM CHANNEL GENE; POLYMORPHIC CAG REPEAT; SMALL-CONDUCTANCE; HKCA3; GENE; DISEQUILIBRIUM; METAANALYSIS; INHIBITION; MUTATIONS; SOFTWARE; DISORDER;

D O I：

10.1016/j.neulet.2010.09.074

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Schizophrenia is a common severe mental illness affecting 0.3-2.0% of the world's population. The potassium channels are thought to have a role in modulating electrical excitability in neurons, regulating calcium signaling in oligodendrocytes and regulating action potential duration in presynaptic terminals and GABA release. Previous studies have reported that some potassium channel genes might be candidate genes for susceptibility to schizophrenia. In the present study, we chose three potassium channel genes, KCNH1, KCNJ10, KCNN3 to investigate the role of potassium channels in schizophrenia by genotyping 23 SNPs (9 in KCNH1, 5 in KCNJ10 and 9 in KCNN3) in a Han Chinese sample consisting of 893 schizophrenia patients and 611 healthy controls. No significant difference in allelic or genotypic frequency was revealed between schizophrenia patients and healthy individuals. Nor was a significant difference in haplotypic distribution detected. MDR analysis revealed no gene-gene interaction within the three potassium channel genes. Our study suggests that the 23 SNPs within the three potassium genes we examined do not play a major role in schizophrenia in the Han Chinese population. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：61 / 65

页数：5

共 34 条

[1] Haploview: analysis and visualization of LD and haplotype maps [J].

Barrett, JC ;

Fry, B ;

Maller, J ;

Daly, MJ .

BIOINFORMATICS, 2005, 21 (02) :263-265

[2] Small-conductance, Ca2+-activated K+ channel SK3 generates age-related memory and LTP deficits [J].

Blank, T ;

Nijholt, I ;

Kye, MJ ;

Radulovic, J ;

Spiess, J .

NATURE NEUROSCIENCE, 2003, 6 (09) :911-912

[3]

BOND CT, 1994, RECEPTOR CHANNEL, V2, pU2

[4] Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophrenia [J].

Bowen, T ;

Guy, CA ;

Craddock, N ;

Cardno, AG ;

Williams, NM ;

Spurlock, G ;

Murphy, KC ;

Jones, LA ;

Gray', M ;

Sanders, RD ;

McCarthy, G ;

Chandy, KG ;

Fantino, E ;

Kalman, K ;

Gutman, GA ;

Gargus, JJ ;

Williams, J ;

McGuffin, P ;

Owen, MJ ;

O'Donovan, MC .

MOLECULAR PSYCHIATRY, 1998, 3 (03) :266-269

[5]

Braff David L, 2005, Dialogues Clin Neurosci, V7, P125

[6]

Braff DL, 1999, AM J PSYCHIAT, V156, P596

[7] EPISODIC ATAXIA MYOKYMIA SYNDROME IS ASSOCIATED WITH POINT MUTATIONS IN THE HUMAN POTASSIUM CHANNEL GENE, KCNA1 [J].

BROWNE, DL ;

GANCHER, ST ;

NUTT, JG ;

BRUNT, ERP ;

SMITH, EA ;

KRAMER, P ;

LITT, M .

NATURE GENETICS, 1994, 8 (02) :136-140

[8] Location of a major susceptibility locus for familiar schizophrenia on chromosome 1q21-q22 [J].

Brzustowicz, LM ;

Hodgkinson, KA ;

Chow, EWC ;

Honer, WG ;

Bassett, AS .

SCIENCE, 2000, 288 (5466) :678-682

[9] Association between variation in the human KCNJ10 potassium ion channel gene and seizure susceptibility [J].

Buono, RJ ;

Lohoff, FW ;

Sander, T ;

Sperling, MR ;

O'Connor, MJ ;

Dlugos, DJ ;

Ryan, SG ;

Golden, GT ;

Zhao, H ;

Scattergood, TM ;

Berrettini, WH ;

Ferraro, TN .

EPILEPSY RESEARCH, 2004, 58 (2-3) :175-183

[10] Isolation of a novel potassium channel gene hSKCa3 containing a polymorphic CAG repeat: a candidate for schizophrenia and bipolar disorder? [J].

Chandy, KG ;

Fantino, E ;

Wittekindt, O ;

Kalman, K ;

Tong, LL ;

Ho, TH ;

Gutman, GA ;

Crocq, MA ;

Ganguli, R ;

Nimgaonkar, V ;

Morris-Rosendahl, DJ ;

Gargus, JJ .

MOLECULAR PSYCHIATRY, 1998, 3 (01) :32-37

← 1 2 3 4 →