Preparation and Characterization of Silk Fibrion and Chitosan Blend Nanofibers by Electrospinning

被引：0

作者：

Cai Zeng-xiao ^{[1
]}

Zhang Kui-hua ^{[1
]}

Fan Lin-peng ^{[1
]}

Wang Hong-sheng ^{[1
]}

He Chuang-long ^{[1
]}

Mo Xiu-mei ^{[1
]}

机构：

[1] Donghua Univ, Coll Chem & Chem Engn & Biol Engn, Biomat & Tissue Engn Lab, Shanghai 201620, Peoples R China

来源：

2010 INTERNATIONAL FORUM ON BIOMEDICAL TEXTILE MATERIALS, PROCEEDINGS | 2010年

关键词：

silk fibrion; chitosan; electrospinning; nanofibers; biomaterials; IN-VITRO EVALUATION; FIBROIN; CONFORMATION; CELLS;

D O I：

暂无

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

In the present study, Silk fibroin(SF)/chitosan(CS) were fabricated by electrospunning. The diameter of SF/CS blend nanofibers decreased gradually from 484 to 105 nm with the increase of CS content. The conformation change was investigated by means of Fourier Transform Infrared (FTIR) spectra and X-Ray diffraction. The SF/CS nanofibers showed characteristic adsorption peaks of the random coil structure of SF, and the addition of CS did not induce SF conformation change from alpha-helix to beta- sheet. With the treatment of glutaraldehyde(GTA) vapor, the SF conformated from alpha-helix to beta-sheet, and the stability of SF/CS membranes were significantly enhanced. The electrospining SF/CS blend nanofibers are designed to mimic the native extracellular matrix and can be used as tissue engineering scaffolds.

引用

页码：245 / 249

页数：5

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