Biomimetic Hydrogels to Promote Wound Healing

被引：140
作者：
Fan, Fei [1 ]
Saha, Sanjoy [1 ]
Hanjaya-Putra, Donny [1 ,2 ,3 ,4 ]
机构：
[1] Univ Notre Dame, Dept Aerosp & Mech Engn, Bioengn Grad Program, Notre Dame, IN 46556 USA
[2] Univ Notre Dame, Dept Chem & Biomol Engn, Notre Dame, IN 46556 USA
[3] Univ Notre Dame, Harper Canc Res Inst, Notre Dame, IN 46556 USA
[4] Univ Notre Dame, Ctr Stem Cells & Regenerat Med, Notre Dame, IN 46556 USA
来源：
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | 2021年 / 9卷
关键词：
hydrogels; wound healing; stem cells; angiogenesis; wound dressing; HYALURONIC-ACID HYDROGELS; MACROPHAGE RECRUITMENT AGENT; FIBROBLAST-GROWTH-FACTOR; ENZYMATIC CROSS-LINKING; MESENCHYMAL STEM-CELLS; IN-SITU; EXTRACELLULAR-MATRIX; GELATIN HYDROGEL; INJECTABLE HYDROGELS; CHITOSAN HYDROGELS;
D O I：
10.3389/fbioe.2021.718377
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Wound healing is a common physiological process which consists of a sequence of molecular and cellular events that occur following the onset of a tissue lesion in order to reconstitute barrier between body and external environment. The inherent properties of hydrogels allow the damaged tissue to heal by supporting a hydrated environment which has long been explored in wound management to aid in autolytic debridement. However, chronic non-healing wounds require added therapeutic features that can be achieved by incorporation of biomolecules and supporting cells to promote faster and better healing outcomes. In recent decades, numerous hydrogels have been developed and modified to match the time scale for distinct stages of wound healing. This review will discuss the effects of various types of hydrogels on wound pathophysiology, as well as the ideal characteristics of hydrogels for wound healing, crosslinking mechanism, fabrication techniques and design considerations of hydrogel engineering. Finally, several challenges related to adopting hydrogels to promote wound healing and future perspectives are discussed.</p>
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页数：24
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