Identification of cDNA coding for a homologue to mammalian leptin from pufferfish, Takifugu rubripes

被引：201

作者：

Kurokawa, T ^{[1
]}

Uji, S ^{[1
]}

Suzuki, T ^{[1
]}

机构：

[1] Natl Res Inst Aquaculture, Fisheries Res Agcy, Nansei, Mie 5160193, Japan

来源：

PEPTIDES | 2005年 / 26卷 / 05期

关键词：

leptin; cDNA; Takifugu rubripes; fish; amphibian;

D O I：

10.1016/j.peptides.2004.12.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We identified cDNA coding for a homologue to mammalian leptin in puffer, Takifugu rubripes, using genomic synteny around the human leptin gene. In addition to significant sequence homologies, the puffer leptin (pLEP) displays characteristic structural features in common with mammalian leptin. The pLEP mRNA was expressed mostly in the liver that contained abundant lipids. In addition, homologues to pLEP were found in the databanks for three fish species (salmon, medaka, and Tetraodon) and two amphibians (salamander andXenopus). The phylogenetic analysis shows rapid rates of molecular divergence among leptins from different vertebrate classes, but not between mammals and avians. (c) 2004 Elsevier Inc. All rights reserved.

引用

页码：745 / 750

页数：6

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