The Effect of Sumac Rhuscoriaria L. Powder on Serum Glycemic Status, ApoB, ApoA-I and Total Antioxidant Capacity in Type 2 Diabetic Patients

被引:0
作者
Shidfar, Farzad [1 ]
Rahideh, Seyedeh Tayebeh [1 ]
Rajab, Asadollah [2 ]
Khandozi, Nafise [1 ]
Hosseini, Sharieh [3 ]
Shidfar, Shahrzad [4 ]
Mojab, Faraz [5 ]
机构
[1] Iran Univ Med Sci, Res Inst Islamic & Complementary Med, Tehran, Iran
[2] Iranian Diabet Assoc, Tehran, Iran
[3] Islamic Azad Univ, Robat Karim Branch, Robat Karim, Iran
[4] Univ Massachusetts, Worcester Mem Hosp, Worcester, MA 01605 USA
[5] Shahid Beheshti Univ Med Sci, Sch Pharm, Tehran, Iran
来源
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH | 2014年 / 13卷 / 04期
关键词
Sumac; Glycemic status; Apolipoprotein; Total antioxidant capacity; Diabetes; RHUS-CORIARIA L; A-I; EXTRACTS; INSULIN; GLUCOSE; TRIAL; FRUIT; RATIO;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Sumac Rhuscoriaria L. is used as an herbal remedy in traditional medicine. The aim of this study was to determine the effects of sumac (R. coriaria) on serum glycemic status, apolipoprotein (apo) B, apoA-I and total antioxidant capacity (TAC) in type 2 diabetic patients. This double blind randomized controlled clinical trial was conducted on 41type 2 diabetic volunteers randomly assigned into 3g/day sumac powder (n=22) or placebo (n=19) groups over 3 months. Blood samples were collected before and after the intervention. Serum glucose and HbA1c were measured using enzymatic and turbidimetric inhibition immunoassay methods, respectively. ApoB, apoA-I and TAC were determined using turbidimetric immunoassay and spectrophotometric methods, respectively. There were significant decreases in serum glucose and HbA1c and als oapoB levels at the end of study compared with initial values (P< 0.0001, P= 0.002 and P< 0.0001, respectively). Also, there was a significant difference in HbA1c and TAC levels between placebo and sumac groups at the end of study (P< 0.05). In sumac group, there were significant increase in apoA-I and TAC (P< 0.0001) compared with initial values. The mean of differences of serum glucose, HbA1c, apoB, apoA-I, apoB/apoA-I ratio and TAC between groups were significant (P< 0.05). In conclusion, these results showed the favorite effect of sumac consumption on serum glycemic status, apoB, apoA-I and TAC levels in in type 2 diabetic patients.
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页码:1249 / 1255
页数:7
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