The SARS-CoV-2 Nucleocapsid Protein and Its Role in Viral Structure, Biological Functions, and a Potential Target for Drug or Vaccine Mitigation

被引：253

作者：

Bai, Zhihua ^{[1
,2
]}

Cao, Ying ^{[1
,3
]}

Liu, Wenjun ^{[1
,2
,4
]}

Li, Jing ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China

[2] Univ Chinese Acad Sci, Savaid Med Sch, Beijing 100049, Peoples R China

[3] Chinese Acad Sci, Wuhan Inst Virol, CAS Key Lab Special Pathogens & Biosafety, Wuhan 430071, Peoples R China

[4] Chinese Acad Sci, Ctr Biosafety Mega Sci, Inst Microbiol, Beijing 100101, Peoples R China

来源：

VIRUSES-BASEL | 2021年 / 13卷 / 06期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

SARS-CoV-2; nucleocapsid protein; structure; biological function; vaccine; RESPIRATORY SYNDROME-CORONAVIRUS; SARS-ASSOCIATED CORONAVIRUS; DIMERIZATION DOMAIN; SELF-ASSOCIATION; TERMINAL DOMAIN; VIRUS; CELL; MULTIMERIZATION; OLIGOMERIZATION; IDENTIFICATION;

D O I：

10.3390/v13061115

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on the world is still expanding. Thus, there is an urgent need to better understand this novel virus and find a way to control its spread. Like other coronaviruses, the nucleocapsid (N) protein is one of the most crucial structural components of SARS-CoV-2. This protein shares 90% homology with the severe acute respiratory syndrome coronavirus N protein, implying functional significance. Based on the evolutionary conservation of the N protein in coronavirus, we reviewed the currently available knowledge regarding the SARS-CoV-2 N protein in terms of structure, biological functions, and clinical application as a drug target or vaccine candidate.

引用

页数：13

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