Can blood glucose levels predict biochemical and haematological abnormalities in COVID-19 patients - Experience from a tertiary care hospital in Balochistan

被引:0
作者
Bashir, Saima [1 ]
Ahmad, Azeema [1 ]
Iqbal, Hamid [1 ]
Nasir, Shafia [1 ]
Nawaz, Khurram Haq [2 ]
Ayub, Zeeshan [3 ]
机构
[1] Combined Mil Hosp, Dept Pathol, Quetta, Pakistan
[2] Combined Mil Hosp, Dept Med, Quetta, Pakistan
[3] Combined Mil Hosp, Dept ENT, Quetta, Pakistan
关键词
Biochemical; COVID-19; Hyperglycaemia; OUTCOMES;
D O I
10.47391/JPMA.3803
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective:To find out the association between poor glycaemic levels and biochemical and haematological abnormalities in patients of corona virus disease-2019. Methods:The prospective, observational, cohort study was conducted at the Combined Military Hospital, Quetta, Pakistan, from September 2020 to February 2021, and comprised all patients who tested positive for coronavirus disease-2019 on polymerase chain reaction test and were subsequently admitted. The patients were divided into two groups on the basis of random blood glucose level at the time of admission; >= 11.1mmol/l (206mg/dl) in group A and 4-11.1mmol (74-206mg/dl) in group B. Association between categorical variables was evaluated and hazard ratio was measured. Data was analysed using SPSS 21. Results: Of the 349 patients, there were 56(16%) in group A; 40(71.4%) males and 16(28.6%) females with age range 39-61 years. There were 293(84%) subjects in group B; 239(81.5%) males and 54(18.5%) females with age range 27-53 years. Overall, 75(21.4%) patients were known type 2 diabetics. A significant association was found between poor glycaemic control and raised levels of C-reactive protein, lactate dehydrogenase, ferritin, erythrocyte sedimentation rate, troponin, creative kinase, creative kinase-MB, alanine aminotransferase, creatinine and D-dimers (p<0.05). Inter-group differences were significant for acute kidney injury, acute liver injury, Intensive care unit admission for coagulation abnormalities and for overall mortality (p<0.05). Conclusion: Poor glycaemic control was found to be a risk factor for developing multisystem complications in patients of coronavirus disease-2019.
引用
收藏
页码:1369 / 1372
页数:4
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