CD93 promotes acute myeloid leukemia development and is a potential therapeutic target

被引：10

作者：

Jia, Jie ^{[1
]}

Liu, Bin ^{[2
]}

Wang, Dandan ^{[1
]}

Wang, Xiaohong ^{[1
]}

Song, Lingrui ^{[1
]}

Ren, Yanzhang ^{[1
]}

Guo, Zhaoming ^{[1
]}

Ma, Kun ^{[1
]}

Cui, Changhao ^{[1
]}

机构：

[1] Dalian Univ Technol, Sch Life & Pharmaceut Sci, Panjin 124221, Peoples R China

[2] Dalian Univ Technol, Liaoning Canc Hosp & Inst, Canc Hosp, Shenyang 110042, Peoples R China

来源：

EXPERIMENTAL CELL RESEARCH | 2022年 / 420卷 / 02期

关键词：

Acute myeloid leukemia; CD93; SHP-2; Syk; CREB cascade; mAb; RECEPTOR-ALPHA CHAIN; STEM-CELLS; EXPRESSION; SYK; PROTOONCOGENE; ACTIVATION; SURFACE; MARKER; KINASE;

D O I：

10.1016/j.yexcr.2022.113361

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CD93 is a transmembrane receptor belonging to the Group XIV C-Type lectin family. It is expressed in a variety of cellular types such as monocytes, neutrophils, platelets, microglia, and endothelial cells. CD93 has been reported to play important roles in cell proliferation, cell migration, and tumor angiogenesis. Here, we show CD93 is highly expressed in M4 and M5 subtypes of acute myeloid leukemia (AML) patients, and highly expressed in leukemia stem cells, AML progenitor cells, as well as more differentiated AML cells. We found that CD93 pro-motes AML cell proliferation, while CD93 deficient AML cells commit to differentiation. We further show that CD93 exerts its proliferative function through downstream SHP-2/Syk/CREB cascade in AML cells. Moreover, human AML cells treated with CD93 mAb combined with alpha MFc-NC-DM1 (an IgG Fc specific antibody conju-gated to maytansinoid DM1), showed a striking reduction of proliferation. Our study revealed that CD93 is a critical participator of AML development and provides a potential therapeutic cell surface target. (160 words).

引用

页数：7

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