Structure-activity relationship of flavonoid bifunctional inhibitors against Zika virus infection

被引：40
|
作者：
Zou, Min [1 ]
Liu, Hongmiao [1 ]
Li, Jingyan [1 ]
Yao, Xingang [1 ]
Chen, Yi [1 ]
Ke, Changwen [2 ]
Liu, Shuwen [1 ]
机构：
[1] Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou Key Lab Drug Res Emerging Virus Prevent, 1838 Northern Guangzhou Rd, Guangzhou 510515, Peoples R China
[2] Guangdong Prov Ctr Dis Control & Prevent, Guangzhou, Guangdong, Peoples R China
来源：
BIOCHEMICAL PHARMACOLOGY | 2020年 / 177卷
关键词：
Zika virus; Flavonoids; Antiviral; Entry inhibitors; Protease; NS2B-NS3; PROTEASE; FLAVIVIRUS; COMPOUND; SURAMIN; CELLS; ENTRY; REPLICATION; EGCG;
D O I：
10.1016/j.bcp.2020.113962
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Zika virus (ZIKV) infection is a global public health problem due to its rapid spread and the possibility of causing microcephaly. Currently, no specific antivirals against ZIKV are available for treatment. In the present study, several flavonoids (galangin, kaempferide, quercetin, myricetin and EGCG) were found to reduce ZIKV induced plaques and viral RNA copies with negligible cytotoxic effects on host cells. In addition, inhibition of ZIKV propagation by flavonoids showed structure-activity relationship. Our results demonstrate flavonoids as inhibitors of ZIKV entry and NS2B-NS3 protease. Hence, these flavonoids could be used as potential bifunctional drugs for treating ZIKV infections.
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页数：9
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