Large shifts in pathogen virulence relate to host population structure

被引：145
作者：
Boots, M
Hudson, PJ
Sasaki, A
机构：
[1] Univ Sheffield, Dept Anim & Plant Sci, Sheffield S10 2TN, S Yorkshire, England
[2] Penn State Univ, Dept Biol, Mueller Lab, University Pk, PA 16802 USA
[3] Kyushu Univ, Math Biol Lab, Higashi Ku, Fukuoka 812, Japan
来源：
SCIENCE | 2004年 / 303卷 / 5659期
关键词：
D O I：
10.1126/science.1088542
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Theory on the evolution of virulence generally predicts selection for an optimal level of virulence determined by trade-offs with transmission and/or recovery. Here we consider the evolution of pathogen virulence in hosts who acquire long-lived immunity and live in a spatially structured population. We show theoretically that large shifts in virulence may occur in pathogen populations as a result of a bistability in evolutionary dynamics caused by the local contact or social population structure of the host. This model provides an explanation for the rapid emergence of the highly virulent strains of rabbit hemorrhagic disease virus.
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页码：842 / 844
页数：3
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