A limited sampling strategy for the simultaneous estimation of tacrolimus, mycophenolic acid and unbound prednisolone exposure in adult kidney transplant recipients

被引：19
作者：
Barraclough, Katherine A. [1 ]
Isbel, Nicole M. [1 ]
Johnson, David W. [1 ]
Hawley, Carmel M. [1 ]
Lee, Katie J. [2 ]
Mcwhinney, Brett C. [3 ]
Ungerer, Jacobus P. [3 ]
Campbell, Scott B. [1 ]
Leary, Diana R. [1 ]
Staatz, Christine E. [2 ]
机构：
[1] Univ Queensland, Princess Alexandra Hosp, Dept Nephrol, Brisbane, Qld 4102, Australia
[2] Univ Queensland, Sch Pharm, Brisbane, Qld 4102, Australia
[3] Royal Brisbane & Womens Hosp, Dept Chem Pathol, Brisbane, Qld, Australia
来源：
NEPHROLOGY | 2012年 / 17卷 / 03期
基金：
英国医学研究理事会;
关键词：
area under the concentration-time curve; limited sampling strategy; mycophenolic acid; prednisolone; tacrolimus; SOLID-ORGAN TRANSPLANTATION; TANDEM MASS-SPECTROMETRY; UNDER-THE-CURVE; PHARMACOKINETICS; AREA; PERFORMANCE;
D O I：
10.1111/j.1440-1797.2011.01560.x
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Aim: The aim of this study was to develop a limited sampling strategy (LSS) for the simultaneous estimation of exposure to tacrolimus, mycophenolic acid and unbound prednisolone in adult kidney transplant recipients. Methods: Tacrolimus, mycophenolic acid and unbound prednisolone area under the concentration- time curve profiles from 0 to 12 h post dose (AUC0- 12) were collected from 20 subjects. Multiple linear regression analyses were performed to develop a LSS enabling the simultaneous estimation of exposure to all three drugs. Median percentage prediction error and median absolute percentage prediction error were calculated via jackknife analysis to evaluate bias and imprecision. Results: LSS showed superior ability to predict exposure compared with single concentration- time points. A LSS incorporating concentration measurements at 0.5 h (C0.5), 2 h (C2) and 4 h (C4) post dose displayed acceptable predictive ability for all three drugs. Conclusion: This LSS may serve as a useful research tool for further investigation of the utility of concentration monitoring of these medications.
引用
收藏
页码：294 / 299
页数：6
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