Autologous chondrocyte implantation: where do we stand now?

被引:19
作者
Gikas, P. D. [1 ]
Aston, W. J. S.
Briggs, T. W. R.
机构
[1] Royal Natl Orthopaed Hosp, Bone Tumour Unit, Stanmore HA7 4LP, Middx, England
关键词
D O I
10.1007/s00776-007-1228-9
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Chondral damage to the young knee is common. In symptomatic patients current surgical treatment has focused on filling the defect with fibrocartilage; however, this tissue has poor resistance to shear forces, leading to failure and the onset of degenerative osteoarthritis.
引用
收藏
页码:283 / 292
页数:10
相关论文
共 46 条
[1]  
Alberts B., 2002, Molecular Biology of The Cell, V4th
[2]   REPAIR OF ARTICULAR SURFACES BY ALLOGRAFTS OF ARTICULAR AND GROWTH-PLATE CARTILAGE [J].
ASTON, JE ;
BENTLEY, G .
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 1986, 68 (01) :29-35
[3]   Role of cytokines, acute-phase proteins, and chemokines in the progression of rheumatoid arthritis [J].
Badolato, R ;
Oppenheim, JJ .
SEMINARS IN ARTHRITIS AND RHEUMATISM, 1996, 26 (02) :526-538
[4]   A prospective, randomised comparison of autologous chondrocyte implantation versus mosaicplasty for osteochondral defects in the knee [J].
Bentley, G ;
Biant, LC ;
Carrington, RWJ ;
Akmal, M ;
Goldberg, A ;
Williams, AM ;
Skinner, JA ;
Pringle, J .
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 2003, 85B (02) :223-230
[5]   Histological evaluation of chondral defects after autologous chondrocyte implantation of the knee [J].
Briggs, TWR ;
Mahroof, S ;
David, LA ;
Flannelly, DJ ;
Pringle, J ;
Bayliss, M .
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 2003, 85B (07) :1077-1083
[6]   Influence of fibrin sealant (Tisseel(R)) on osteochondral defect repair in the rabbit knee [J].
Brittberg, M ;
SjogrenJansson, E ;
Lindahl, A ;
Peterson, L .
BIOMATERIALS, 1997, 18 (03) :235-242
[7]   TREATMENT OF DEEP CARTILAGE DEFECTS IN THE KNEE WITH AUTOLOGOUS CHONDROCYTE TRANSPLANTATION [J].
BRITTBERG, M ;
LINDAHL, A ;
NILSSON, A ;
OHLSSON, C ;
ISAKSSON, O ;
PETERSON, L .
NEW ENGLAND JOURNAL OF MEDICINE, 1994, 331 (14) :889-895
[8]  
BUCKWALTER JA, 1987, INJURY REPAIR MUSCUL, P405
[9]  
Clement JH, 2005, INT J ONCOL, V27, P401
[10]  
Comper W. D., 1991, Cartilage: molecular aspects, P59