Increased macrophage chemoattractant protein-1 in cerebrospinal fluid precedes and predicts simian immunodeficiency virus encephalitis

被引:133
作者
Zink, MC
Coleman, GD
Mankowski, JL
Adams, RJ
Tarwater, PM
Fox, K
Clements, JE
机构
[1] Johns Hopkins Univ, Sch Med, Div Comparat Med, Baltimore, MD 21287 USA
[2] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21287 USA
[3] Johns Hopkins Univ, Sch Med, Dept Mol Biol & Genet, Baltimore, MD 21287 USA
[4] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21287 USA
[5] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21287 USA
[6] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, W Harry Feinstone Dept Mol Microbiol & Immunol, Baltimore, MD 21287 USA
关键词
D O I
10.1086/323478
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Macrophage chemoattractant protein-1 (MCP-1) may be a key trigger for the influx of macrophages into the brain in human immunodeficiency virus (HIV) encephalitis. In this study, simian immunodeficiency virus-infected macaques that developed moderate-to-severe encephalitis had significantly higher MCP-1 levels in cerebrospinal fluid (CSF) than in plasma as early as 28 days after inoculation, which was before the development of brain lesions. In contrast, CSF:plasma MCP-1 ratios remained constant at preinoculation levels in macaques that developed minimal or no encephalitis. Abundant MCP-1 protein and mRNA were detected in both macrophages and astrocytes in the brain. Macaques with increased MCP-1 in CSF had significantly greater expression of markers of macrophage and microglia activation and infiltration (CD68; P = .003) and astrocyte activation (glial fibrillary acidic protein; P = .019 and P = .031 and in white and gray matter, respectively). The results suggest that the CSF:plasma MCP-1 ratio may be a valuable prognostic marker for the development of HIV-induced central nervous system disease.
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收藏
页码:1015 / 1021
页数:7
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