Organocatalytic enantioselective functionalization of indoles in the carbocyclic ring with cyclic imines

被引：23

作者：

Vila, Carlos ^{[1
]}

Tortosa, Arturo ^{[1
]}

Blay, Gonzalo ^{[1
]}

Carmen Munoz, M. ^{[2
]}

Pedro, Jose R. ^{[1
]}

机构：

[1] Univ Valencia, Fac Quim, Dept Quim Organ, Dr Moliner 50, E-46100 Valencia, Spain

[2] Univ Politecn Valencia, Dept Fis Aplicada, Camino Vera S-N, E-46022 Valencia, Spain

来源：

NEW JOURNAL OF CHEMISTRY | 2019年 / 43卷 / 01期

关键词：

FRIEDEL-CRAFTS REACTION; ASYMMETRIC-SYNTHESIS; ALKYLATION; KETIMINES; HYDROXYINDOLES; CONSTRUCTION; DERIVATIVES; INHIBITORS;

D O I：

10.1039/c8nj05577g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An organocatalytic enantioselective functionalization in the carbocyclic ring of indoles with benzoxathiazine 2,2-dioxides is described using a quinine-derived bifunctional organocatalyst. This aza-Friedel-Crafts reaction provides 4-indolyl, 5-indolyl and 7-indolyl sulfamidate derivatives in good yields (up to 99%) and with moderate to high enantioselectivities (up to 86% ee).

引用

页码：130 / 134

页数：5

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