The specificity of a chlorphenamine-imprinted polymer and its application

被引：32

作者：

Chen, W

Liu, F

Zhang, XM

Li, KA ^{[1
]}

Tong, SY

机构：

[1] Beijing Univ, Dept Chem, Beijing 100871, Peoples R China

[2] Dezhou Med Co Ltd, Shandong, Peoples R China

来源：

TALANTA | 2001年 / 55卷 / 01期

关键词：

chlorphenamine-imprinted polymer; solid-phase extraction; molecular imprinted polymer (MIP);

D O I：

10.1016/S0039-9140(01)00328-9

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A chlorphenamine-imprinted polymer was prepared in this study. Chromatographic analysis showed that the retentivity and selectivity of the imprinted polymer were greatly strengthened through molecular imprinting. As a consequence, chlorphenamine could be easily separated from diphenhydramine. Ionic interaction was proved to be the main power for the imprinted polymer to bind chlorphenamine. The strong extraction ability of the imprinted polymer for chlorphenamine in aqueous solution was evaluated further. It was shown that chlorphenamine, as low as 0.02 mu mol l(-1), could be concentrated by 50 times with a recovery of more than 90% at pH 5. This study gave the potential of using the imprinted polymer for solid-phase extraction of practical samples. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：29 / 34

页数：6

共 20 条

[1] Application of molecular imprinting to the development of aqueous buffer and organic solvent based radioligand binding assays for (S)-propranolol [J].