Cardiac H2S Generation Is Reduced in Ageing Diabetic Mice

被引：62

作者：

Jin, Sheng ^{[1
,2
,3
]}

Pu, Shi-Xin ^{[1
,2
]}

Hou, Cui-Lan ^{[1
,2
]}

Ma, Fen-Fen ^{[4
]}

Li, Na ^{[1
,2
]}

Li, Xing-Hui ^{[1
,2
]}

Tan, Bo ^{[4
]}

Tao, Bei-Bei ^{[1
,2
]}

Wang, Ming-Jie ^{[1
,2
]}

Zhu, Yi-Chun ^{[1
,2
]}

机构：

[1] Fudan Univ, Shanghai Med Coll, Shanghai Key Lab Bioact Small Mol, Shanghai 200032, Peoples R China

[2] Fudan Univ, Shanghai Med Coll, Res Ctr Aging & Med, Dept Physiol & Pathophysiol, Shanghai 200032, Peoples R China

[3] Hebei Med Univ, Dept Physiol, Anhua 050017, Hebei, Peoples R China

[4] Fudan Univ, Sch Pharm, Dept Pharmacol, Shanghai 201203, Peoples R China

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2015年 / 2015卷

基金：

中国国家自然科学基金;

关键词：

CYSTATHIONINE-GAMMA-LYASE; SYNTHETASE GENE CONTRIBUTES; ACTIVATED PROTEIN-KINASE; HYDROGEN-SULFIDE; OXIDATIVE STRESS; BETA-SYNTHASE; BODY-WEIGHT; URIC-ACID; KAPPA-B; APOPTOSIS;

D O I：

10.1155/2015/758358

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Aims. To examine whether hydrogen sulfide (H2S) generation changed in ageing diabetic mouse hearts. Results. Compared to mice that were fed tap water only, mice that were fed 30% fructose solution for 15 months exhibited typical characteristics of a severe diabetic phenotype with cardiac hypertrophy, fibrosis, and dysfunction. H2S levels in plasma, heart tissues, and urine were significantly reduced in these mice as compared to those in controls. The expression of the H2S-generating enzymes, cystathionine gamma-lyase and 3-mercaptopyruvate sulfurtransferase, was significantly decreased in the hearts of fructose-fed mice, whereas cystathionine-beta-synthase levels were significantly increased. Conclusion. Our results suggest that this ageing diabetic mouse model developed diabetic cardiomyopathy and that H2S levels were reduced in the diabetic heart due to alterations in three H2S-producing enzymes, which may be involved in the pathogenesis of diabetic cardiomyopathy.

引用

页数：14

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