Molecular Functions of Hydrogen Sulfide in Cancer

被引：38

作者：

Shackelford, Rodney E. ^{[1
]}

Mohammad, Islam Z. ^{[1
]}

Meram, Andrew T. ^{[2
]}

Kim, David ^{[2
]}

Alotaibi, Fawaz ^{[2
]}

Patel, Stavan ^{[2
]}

Ghali, Ghali E. ^{[2
]}

Kevil, Christopher G. ^{[1
]}

机构：

[1] LSU Hlth Sci Ctr Shreveport, Dept Pathol & Translat Pathobiol, Shreveport, LA 71130 USA

[2] Louisiana State Univ Hlth Sci Ctr, Dept Oral & Maxillofacial Head & Neck Surg, Head & Neck Oncol Microvasc Reconstruct Surg, Shreveport, LA 71130 USA

来源：

PATHOPHYSIOLOGY | 2021年 / 28卷 / 03期

关键词：

hydrogen sulfide; H2S; cancer; cystathionine & beta; -synthase; cystathionine & gamma; -lyase; 3-mercaptopyruvate sulfurtransferase; CYSTATHIONINE-BETA-SYNTHASE; UP-REGULATION; CELL-PROLIFERATION; NITRIC-OXIDE; INHIBITION; H2S; DIAGNOSIS; BIOENERGETICS; CARCINOMA; PROTECTS;

D O I：

10.3390/pathophysiology28030028

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Hydrogen sulfide (H2S) is a gasotransmitter that exerts a multitude of functions in both physiologic and pathophysiologic processes. H2S-synthesizing enzymes are increased in a variety of human malignancies, including colon, prostate, breast, renal, urothelial, ovarian, oral squamous cell, and thyroid cancers. In cancer, H2S promotes tumor growth, cellular and mitochondrial bioenergetics, migration, invasion, angiogenesis, tumor blood flow, metastasis, epithelia-mesenchymal transition, DNA repair, protein sulfhydration, and chemotherapy resistance Additionally, in some malignancies, increased H2S-synthesizing enzyme expression correlates with a worse prognosis and a higher tumor stage. Here we review the role of H2S in cancer, with an emphasis on the molecular mechanisms by which H2S promotes cancer development, progression, dedifferentiation, and metastasis.

引用

页码：437 / 456

页数：20

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