Iron-catalyzed C-N bond formation via oxidative Csp3-H bond functionalization adjacent to nitrogen in amides and anilines: Synthesis of N-alkyl and N-benzyl azoles

被引：24

作者：

Saidulu, G. ^{[1
]}

Kumar, R. Arun ^{[1
]}

Reddy, K. Rajender ^{[1
]}

机构：

[1] Indian Inst Chem Technol, CSIR, Inorgan & Phys Chem Div, Hyderabad 500007, Telangana State, India

来源：

TETRAHEDRON LETTERS | 2015年 / 56卷 / 28期

关键词：

Iron; Oxidative coupling; Peroxide; Carbon-nitrogen bond; Azole; DEHYDROGENATIVE COUPLING REACTION; H BOND; TERTIARY-AMINES; VISIBLE-LIGHT; HETEROCYCLIC CARBENES; ANTIFUNGAL AGENTS; MOLECULAR DOCKING; HYDROGEN-PEROXIDE; ACTIVATION; DERIVATIVES;

D O I：

10.1016/j.tetlet.2015.05.048

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Iron catalyzed oxidative protocol was developed to couple azoles with amides to generate N-alkylazole derivatives in moderate to excellent yields using tertiarybutyl hydroperoxide as an oxidant under mild reaction conditions. Furthermore, this protocol explored to couple azoles with N-alkylanilines, unexpectedly N-benzyl azoles were obtained as major products under these oxidative conditions. (C) 2015 Elsevier Ltd. All rights reserved.

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页码：4200 / 4203

页数：4

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