The folate way to T cell fate

被引：6

作者：

de Candia, Paola ^{[1
]}

Matarese, Giuseppe ^{[1
,2
]}

机构：

[1] Univ Napoli Federico II, Treg Cell Lab, Dipartimento Med Mol & Biotecnol Med, Naples, Italy

[2] CNR, Lab Immunol, Ist Endocrinol & Oncol Sperimentale G Salvatore, Naples, Italy

来源：

IMMUNITY | 2022年 / 55卷 / 01期

关键词：

METABOLISM;

D O I：

10.1016/j.immuni.2021.12.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The role of folate-dependent one carbon (1C) metabolism in CD4(+) T cell polarization is incompletely understood. In this issue of Immunity, Sugiura et al. (2021) provide evidence that blocking the 1C metabolic enzyme MTHFD2 may curb pro-inflammatory CD4(+)T cells, while redirecting them toward a regulatory T cell phenotype.

引用

页码：1 / +

页数：3

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