Clostridium difficile infection diagnosis

被引：4

作者：

Eckert, C. ^{[1
]}

Lalande, V. ^{[1
,2
]}

Barbut, F. ^{[1
,3
]}

机构：

[1] Univ Paris 06, Bacteriol Lab, Lab Clostridium Difficile, CNR Anaerobies & Botulisme, F-75571 Paris 12, France

[2] Hop St Antoine, AP HP, Serv Bacteriol, F-75012 Paris, France

[3] Hop St Antoine, AP HP, Unite Hyg & Lutte Infect Nosocomiales, F-75571 Paris 12, France

来源：

JOURNAL DES ANTI-INFECTIEUX | 2011年 / 13卷 / 02期

关键词：

Clostridium difficile; Toxins; Diagnosis; GDH; Real-time PCR; Culture; CLINICAL MICROBIOLOGY; EUROPEAN-SOCIETY; TOXIN-A; DIARRHEA; ADULTS; PCR; EPIDEMIOLOGY; GUIDELINES; ANTIBODY;

D O I：

10.1016/j.antinf.2011.03.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Incidence of Clostridium difficile infections has significantly increased in the US, Canada and Europe over the last 10 years, bringing to the forefront the need of a reliable and rapid diagnosis. This diagnosis is based on toxin detection or on the recovery of a toxigenic strain in diarrhoeal stools. Many tests are now available; some can detect toxins, bacteria or their components, and some detect the toxin genes. However, the multiplicity of methods does not facilitate the choice of clinical labs; moreover, none of the methods satisfy all the criteria of an ideal method in terms of sensitivity, specificity, rapidity and cost. Currently, the best strategy is based on a 2- or 3-step approach. (C) 2011 Elsevier Masson SAS. All rights reserved.

引用

收藏

页码：67 / 73

页数：7

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