Isosorbide dinitrate spray as therapeutic strategy for treatment of chronic venous ulcers

被引：11

作者：

Sanchez-Vazquez, Rene ^{[1
]}

Briseno-Rodriguez, G. ^{[1
]}

Cardona-Munoz, Ernesto German ^{[1
]}

Galvez-Gastelum, Francisco Javier ^{[2
]}

Totsuka-Sutto, Silvia Elena ^{[1
]}

Garcia-Benavides, Leonel ^{[1
,2
]}

机构：

[1] CUCS, Unidad Invest Cardiovasc, Guadalajara, Jalisco, Mexico

[2] Univ Guadalajara, Guadalajara 44430, Jalisco, Mexico

来源：

ANGIOLOGY | 2008年 / 59卷 / 01期

关键词：

ulceration; hypertension; vasodilator; nitric oxide;

D O I：

10.1177/0003319707303700

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Venous ulcers are the most common form of leg ulcers, which induce lesion because of the loss of substances deposited on the damaged skin. Isosorbide dinitrate is a vasodilator with effects on both arteries and veins and induces opening of vascular layers. The objective is to study the effects of isosorbide dinitrate-spray in patients with chronic venous ulcers. Forty-five patients of both sexes with chronic venous ulcers were randomized to receive isosorbide dinitrate or placebo sprays daily for 3 months. The ulcers were measured and clinical characteristics were taken every 15 days during the treatment. Patients treated with isosorbide dinitrate showed an improvement of the ulcerated area (71.29%) compared with patients treated with placebo (54.35%). The histopathological study indicated an increment in the number of hypertrophic and hyperplasic capillaries. Macroscopically, the isosorbide dinitrate-treatment showed the best results, but it was only during the first 6 weeks of treatment. Patients with chronic venous ulcer receiving isosorbide dinitrate spray showed improvement.

引用

页码：64 / 71

页数：8