Protease-catalyzed direct aldol reaction

被引：34

作者：

Li, Hai-Hong ^{[1
]}

He, Yan-Hong ^{[1
]}

Guan, Zhi ^{[1
]}

机构：

[1] Southwest Univ, Sch Chem & Chem Engn, Chongqing 400715, Peoples R China

来源：

CATALYSIS COMMUNICATIONS | 2011年 / 12卷 / 07期

关键词：

Enzyme catalysis; Alkaline protease; Enantioselectivity; Aldol reaction; ONE-POT SYNTHESIS; ORGANIC MEDIA; ENZYMATIC CATALYSIS; PROMISCUITY; WATER; BIOCATALYSIS; DERIVATIVES; SOLVENTS; ENZYMES; LIPASE;

D O I：

10.1016/j.catcom.2010.12.003

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A new function of BLAP (alkaline protease from Bacillus licheniformis) was first discovered to catalyze direct aldol reactions between aromatic aldehydes and cyclic ketones in an organic medium in the presence of water. The products were obtained in yields of 28-92% with 22-99% ee. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：580 / 582

页数：3

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