Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activity

被引：24
|
作者：
Kitajima, Mariko [1 ]
Iwai, Masumi [1 ]
Kikura-Hanajiri, Ruri [2 ]
Goda, Yukihiro [2 ]
Iida, Mitsuru [3 ]
Yabushita, Hisatoshi [3 ]
Takayama, Hiromitsu [1 ]
机构：
[1] Chiba Univ, Grad Sch Pharmaceut Sci, Inage Ku, Chiba 2638522, Japan
[2] Natl Inst Hlth Sci, Setagaya Ku, Tokyo 1588501, Japan
[3] Otsuka Pharmaceut Co Ltd, Kawaguchi, Tokushima 7710182, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 07期
关键词：
Cannabinoid; CB1; receptor; Antagonist; Indole alkaloid; Iboga; Voacanga; THERAPEUTIC APPLICATIONS; TABERNAEMONTANA;
D O I：
10.1016/j.bmcl.2011.02.036
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Three indole alkaloids, voacamine (1), 3,6-oxidovoacangine (2), and a new alkaloid, 5-hydroxy-3,6-oxidovoacangine (3), isolated from Voacanga africana were found to exhibit potent cannabinoid CB1 receptor antagonistic activity. This is the first example of CB1 antagonists derived from natural alkaloids. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1962 / 1964
页数：3
相关论文
共 50 条
  • [1] The discovery of novel indole-2-carboxamides as cannabinoid CB1 receptor antagonists
    Cowley, Phillip M.
    Baker, James
    Barn, David R.
    Buchanan, Kirsteen I.
    Carlyle, Ian
    Clark, John K.
    Clarkson, Thomas R.
    Deehan, Maureen
    Edwards, Darren
    Goodwin, Richard R.
    Jaap, David
    Kiyoi, Yasuko
    Mort, Chris
    Palin, Ronald
    Prosser, Alan
    Walker, Glenn
    Ward, Nick
    Wishart, Grant
    Young, Trevor
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (01) : 497 - 501
  • [2] Understanding Functional Residues of the Cannabinoid CB1 Receptor for Drug Discovery
    Shim, Joong-Youn
    CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2010, 10 (08) : 779 - 798
  • [3] The CB1 cannabinoid receptor in the brain
    Howlett, AC
    NEUROBIOLOGY OF DISEASE, 1998, 5 (06) : 405 - 416
  • [4] Cannabinoid CB1 Receptor Antagonists
    Thomas, Brian F.
    DRUG DEVELOPMENT RESEARCH, 2009, 70 (08) : 525 - 526
  • [5] CB1 cannabinoid receptor ligands
    Thakur, GA
    Nikas, SP
    Makriyannis, A
    MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2005, 5 (07) : 631 - 640
  • [6] CB1 cannabinoid receptor antagonists
    Barth, F
    ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 40, 2005, 40 : 103 - 118
  • [7] Indole-2-carboxamides as Allosteric Modulators of the Cannabinoid CB1 Receptor
    Piscitelli, Francesco
    Ligresti, Alessia
    La Regina, Giuseppe
    Coluccia, Antonio
    Morera, Ludovica
    Allara, Marco
    Novellino, Ettore
    Di Marzo, Vincenzo
    Silvestri, Romano
    JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (11) : 5627 - 5631
  • [8] Discovery of novel diarylpyrazolyl thiadiazoles as cannabinoid CB1 receptor antagonists
    Seo, Hee Jeong
    Lee, Suk Ho
    Lee, Sung-Han
    Jung, Myung Eun
    Ahn, Kwangwoo
    Kim, Jeongmin
    Lee, Jinhwa
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 237
  • [9] The Cannabinoid CB1 Receptor in Schizophrenia
    Borgan, Faith
    Kokkinou, Michelle
    Howes, Oliver
    BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING, 2021, 6 (06) : 646 - 659
  • [10] Analgesic activity of a new cannabinoid CB1 receptor modulator
    Gurkin, N., V
    Bykov, V. V.
    Bykova, A., V
    Motov, V. S.
    Larchenko, V. V.
    Il'ina, I., V
    Khazanov, V. A.
    Volcho, K. P.
    Salakhutdinov, N. F.
    Vengerovskii, A., I
    BYULLETEN SIBIRSKOY MEDITSINY, 2024, 23 (03):
12345