Frontiers in targeting glioma stem cells

被引：19

作者：

Frosina, Guido ^{[1
]}

机构：

[1] Ist Nazl Ric Canc, Mol Mutagenesis & DNA Repair Unit, I-16132 Genoa, Italy

来源：

EUROPEAN JOURNAL OF CANCER | 2011年 / 47卷 / 04期

关键词：

Glioma; Stem; CD133; Cancer; Resistance; INITIATING CELLS; MALIGNANT GLIOMAS; DNA-DAMAGE; TGF-BETA; SUBVENTRICULAR ZONE; MEDIATED ACTIVATION; KINASE INHIBITORS; GENE-THERAPY; GLIOBLASTOMA; IDENTIFICATION;

D O I：

10.1016/j.ejca.2010.11.017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Patients with glioblastoma multiforme (GBM - WHO grade IV) seldom recover. This is due to the infiltrative nature of these tumours and the presence of cellular populations with ability to escape therapies and drive tumour recurrence and progression. In some cases, these resistant cells exhibit stem properties [glioma stem cells (GSC)]. This article aims at discussing relevant issues on GSC resistance to current therapies and outlines possible and promising avenues in regard to novel therapeutic strategies, such as pharmacological, immunological and viral interventions. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：496 / 507

页数：12

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