Synthesis of new deuterated lipid probes for membrane fluidity measurements

被引：1
|
作者：
Nuss, S
Oudet, P
Mioskowski, C
Lebeau, L
机构：
[1] UNIV LOUIS PASTEUR STRASBOURG 1,CNRS,LAB SYNTHESE BIOORGAN,F-67401 ILLKIRCH GRAFFENS,FRANCE
[2] UNIV STRASBOURG 1,INST GENET & BIOL MOL & CELLULAIRE,F-67404 ILLKIRCH GRAFFENS,FRANCE
来源：
CHEMISTRY AND PHYSICS OF LIPIDS | 1996年 / 84卷 / 01期
关键词：
phospholipid; deuterated lipid; fluidity; H-2-NMR; monolayer;
D O I：
10.1016/S0009-3084(96)02614-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
New phosphatidylcholine analogs have been synthesized in order to be used as probes for membrane fluidity measurements in H-2-NMR experiments. A 1,3-asymmetrical diether glycerophosphatidylcholine pentadeuterated at the glycerol moiety is elaborated starting from propiolic acid in a 8-steps procedure whereas the corresponding monodeuterated compound is prepared from epibromohydrin.
引用
收藏
页码：13 / 20
页数：8
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