Dammarane-type triterpenoid saponins from the flower buds of Panax pseudoginseng with cytotoxic activity

被引：5

作者：

Tran Thi Hong Hanh ^{[1
]}

Pham Thi Cham ^{[1
]}

Do Hoang Anh ^{[1
]}

Nguyen The Cuong ^{[2
]}

Nguyen Quang Trung ^{[3
]}

Tran Hong Quang ^{[1
]}

Nguyen Xuan Cuong ^{[1
]}

Nguyen Hoai Nam ^{[1
]}

Chau Van Minh ^{[1
]}

机构：

[1] Vietnam Acad Sci & Technol VAST, Inst Marine Biochem, Hanoi, Vietnam

[2] VAST, Inst Ecol & Biol Resources, Hanoi, Vietnam

[3] VAST, Ctr Res & Technol Transfer, Hanoi, Vietnam

来源：

NATURAL PRODUCT RESEARCH | 2022年 / 36卷 / 17期

关键词：

Panax pseudoginseng; Araliaceae; dammarane-type saponin; cytotoxicity; INDIAN GINSENG; LEAVES; ROOTS;

D O I：

10.1080/14786419.2021.1984908

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Phytochemical investigation of a methanol extract of Panax pseudoginseng flower buds resulted in the isolation of 22 dammarane-type triterpenoid saponins, including three new compounds, pseudoginsenosides A-C (1-3), and 19 known analogs. Their chemical structures were identified by the comprehensive spectroscopic methods, including 1 D and 2 D NMR and mass spectra. In addition, their cytotoxic effects toward three human carcinoma cell lines, including liver (HepG2), breast (MCF7), and lung (A549) were also evaluated.

引用

页码：4349 / 4357

页数：9

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