Defining the primary research question in veterinary clinical studies

被引:5
作者
Giuffrida, Michelle A. [1 ,2 ]
机构
[1] Univ Penn, Sch Vet Med, Dept Clin Studies Philadelphia, Philadelphia, PA 19104 USA
[2] Univ Calif Davis, Sch Vet Med, Dept Surg & Radiol Sci, Davis, CA 95616 USA
来源
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION | 2016年 / 249卷 / 05期
关键词
ADJUSTMENT; TRIALS;
D O I
10.2460/javma.249.5.547
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
A thoughtful, clearly defined research question should be the foundation of any clinical trial or research study. The research question helps determine key study methods, and defining a specific research question helps avoid problems with inadequate sample size, inappropriate design, or multiple statistical comparisons. Rationales and strategies for formulating research questions and using them to define study protocols are discussed, with a focus on application in clinical trials.
引用
收藏
页码:547 / 551
页数:5
相关论文
共 24 条
  • [1] Bauer Peter, 2003, J Biopharm Stat, V13, P691, DOI 10.1081/BIP-120024203
  • [2] Adjusting for multiple testing - when and how?
    Bender, R
    Lange, S
    [J]. JOURNAL OF CLINICAL EPIDEMIOLOGY, 2001, 54 (04) : 343 - 349
  • [3] Control of selection bias in parallel-group controlled clinical trials in dogs and cats: 97 trials (2000-2005)
    Brown, Dorothy Cimino
    [J]. JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 2006, 229 (06): : 990 - 993
  • [4] Farrugia P, 2010, CAN J SURG, V53, P278
  • [5] Friedmen LM, 2010, FUNDAMENTALS OF CLINICAL TRIALS, FOURTH EDITION, P1
  • [6] Type II error and statistical power in reports of small animal clinical trials
    Giuffrida, Michelle A.
    [J]. JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 2014, 244 (09): : 1075 - 1080
  • [7] Systematic Reviews and Meta-Analysis
    Haase, Steven C.
    [J]. PLASTIC AND RECONSTRUCTIVE SURGERY, 2011, 127 (02) : 955 - 966
  • [8] Special series: Guidance for young investigators - Forming research questions
    Haynes, R. Brian
    [J]. JOURNAL OF CLINICAL EPIDEMIOLOGY, 2006, 59 (09) : 881 - 886
  • [9] Trials to assess equivalence: The importance of rigorous methods
    Jones, E
    Jarvis, P
    Lewis, JA
    Ebbutt, AF
    [J]. BMJ-BRITISH MEDICAL JOURNAL, 1996, 313 (7048): : 36 - 39
  • [10] Lund Elizabeth M., 1998, Journal of Veterinary Internal Medicine, V12, P57