Functional characterization of P-glycoprotein inhibitors and activators using P-glycoprotein substrate binding site probes and MDCK-MDR1 monolayers

被引:0
作者
Taub, ME [1 ]
Podila, L [1 ]
Ely, D [1 ]
机构
[1] Boehringer Ingelheim Pharmaceut, Dept Drug Metab & Pharmacokinet, Ridgefield, CT USA
关键词
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
306
引用
收藏
页码:153 / 153
页数:1
相关论文
共 50 条
  • [21] Structural and functional aspects of P-glycoprotein and its inhibitors
    Mollazadeh, Shirin
    Sahebkar, Amirhossein
    Hadizadeh, Farzin
    Behravan, Javad
    Arabzadeh, Sepideh
    LIFE SCIENCES, 2018, 214 : 118 - 123
  • [22] MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine
    vanHelvoort, A
    Smith, AJ
    Sprong, H
    Fritzsche, I
    Schinkel, AH
    Borst, P
    van Meer, G
    CELL, 1996, 87 (03) : 507 - 517
  • [23] In Silico Characterization of P-Glycoprotein Substrate Entrance Pathways
    Domicevica, Laura
    Paramo, Teresa
    Biggin, Philip C.
    BIOPHYSICAL JOURNAL, 2016, 110 (03) : 141A - 141A
  • [24] P-glycoprotein of the sheep cloning and functional expression in MDCK-cells
    Zahner, D.
    Alber, J.
    Petzinger, E.
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2009, 379 : 9 - 9
  • [25] Characterisation of cerivastatin as a P-glycoprotein substrate:: studies in P-glycoprotein-expressing cell monolayers and mdr1a/b knock-out mice
    Kivistö, KT
    Zukunft, J
    Hofmann, U
    Niemi, M
    Rekersbrink, S
    Schneider, S
    Luippold, G
    Schwab, M
    Eichelbaum, M
    Fromm, MF
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2004, 370 (02) : 124 - 130
  • [26] Substrates, Inhibitors and Activators of P-glycoprotein: Candidates for Radiolabeling and Imaging Perspectives
    Colabufo, Nicola A.
    Berardi, Francesco
    Perrone, Maria Grazia
    Capparelli, Elena
    Cantore, Mariangela
    Inglese, Carmela
    Perrone, Roberto
    CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2010, 10 (17) : 1703 - 1714
  • [27] Characterisation of cerivastatin as a P-glycoprotein substrate: studies in P-glycoprotein-expressing cell monolayers and mdr1a/b knock-out mice
    Kari T. Kivistö
    Jörg Zukunft
    Ute Hofmann
    Mikko Niemi
    Sabine Rekersbrink
    Swetlana Schneider
    Gerd Luippold
    Matthias Schwab
    Michel Eichelbaum
    Martin F. Fromm
    Naunyn-Schmiedeberg's Archives of Pharmacology, 2004, 370 : 124 - 130
  • [28] Transport of opioid peptides by MDR1 P-glycoprotein
    Elferink, RPJO
    MOLECULAR BIOLOGY OF THE CELL, 1996, 7 : 2520 - 2520
  • [29] EXPRESSION OF MDR-1/P-GLYCOPROTEIN IN HUMAN NEUROBLASTOMA
    BATES, SE
    SHIEH, CY
    TSOKOS, M
    AMERICAN JOURNAL OF PATHOLOGY, 1991, 139 (02) : 305 - 315
  • [30] New horizon of MDR1 (P-glycoprotein) study
    Mizutani, T
    Hattori, A
    DRUG METABOLISM REVIEWS, 2005, 37 (03) : 489 - 510