An update on oral drug delivery via intestinal lymphatic transport

被引：132

作者：

Zhang, Zichen ^{[1
]}

Lu, Yi ^{[1
]}

Qi, Jianping ^{[1
]}

Wu, Wei ^{[1
,2
]}

机构：

[1] Fudan Univ, Sch Pharm, Key Lab Smart Drug Delivery MOE, Shanghai 201203, Peoples R China

[2] Fudan Univ, Ctr Med Res & Innovat, Shanghai Pudong Hosp, Pudong Med Ctr, Shanghai 201399, Peoples R China

来源：

ACTA PHARMACEUTICA SINICA B | 2021年 / 11卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Drug delivery; Oral; Lymphatic transport; Drug absorption; Chylomicron; Microfold cell; Drug carriers; Nanoparticles; SOLID LIPID NANOPARTICLES; FLOW BLOCKING APPROACH; FOLLICLE-ASSOCIATED EPITHELIUM; IN-VITRO CHARACTERISTICS; POLYETHYLENE-GLYCOL; 400; PATCH M-CELLS; PEYERS PATCH; POLYMERIC NANOPARTICLES; PHYSICOCHEMICAL PROPERTIES; GASTROINTESTINAL TRANSIT;

D O I：

10.1016/j.apsb.2020.12.022

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Orally administered drug entities have to survive the harsh gastrointestinal environment, penetrate the enteric epithelia and circumvent hepatic metabolism before reaching the systemic circulation. Whereas the gastrointestinal stability can be well maintained by taking proper measures, hepatic metabolism presents as a formidable barrier to drugs suffering from first-pass metabolism. The pharmaceutical academia and industries are seeking alternative pathways for drug transport to circumvent problems associated with the portal pathway. Intestinal lymphatic transport is emerging as a promising pathway to this end. In this review, we intend to provide an updated overview on the rationale, strategies, factors and applications involved in intestinal lymphatic transport. There are mainly two pathways for peroral lymphatic transport-the chylomicron and the microfold cell pathways. The underlying mechanisms are being unraveled gradually and nowadays witness increasing research input and applications. (C) 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

引用

页码：2449 / 2468

页数：20

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