14-3-3 proteins in the nervous system

被引：387
作者：
Berg, D
Holzmann, C
Riess, O
机构：
[1] Univ Tubingen, Inst Human Genet, Dept Med Genet, D-72076 Tubingen, Germany
[2] Hertie Inst Brain Res, D-72076 Tubingen, Germany
[3] Univ Rostock, Dept Med Genet, D-18057 Rostock, Germany
来源：
NATURE REVIEWS NEUROSCIENCE | 2003年 / 4卷 / 09期
关键词：
D O I：
10.1038/nrn1197
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
14- 3- 3 proteins are abundantly expressed in the brain and have been detected in the cerebrospinal fluid of patients with different neurological disorders. Although the function of this family of highly conserved proteins is not completely known, recent evidence indicates their involvement in multiple cellular processes. By their interaction with more than 100 binding partners, 14- 3- 3 proteins modulate the action of proteins that are involved in cell cycle and transcriptional control, signal transduction, intracellular trafficking and regulation of ion channels. The study of some of these interactions is sheding light on the role of 14- 3- 3 proteins in processes such as apoptosis and neurodegeneration.
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页码：752 / 762
页数：11
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