The role of the autophagy in myocardial ischemia/reperfusion injury

被引：287

作者：

Ma, Sai ^{[1
,2
]}

Wang, Yabin ^{[2
]}

Chen, Yundai ^{[1
]}

Cao, Feng ^{[1
,2
]}

机构：

[1] Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, Beijing 100852, Peoples R China

[2] Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Shaanxi, Peoples R China

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2015年 / 1852卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Autophagy; Myocardial ischemia/reperfusion injury; ISCHEMIA-REPERFUSION INJURY; INITIATING KINASE ULK1; CARDIOMYOCYTE AUTOPHAGY; MITOCHONDRIAL AUTOPHAGY; CARDIAC MYOCYTES; HEART-DISEASE; AMPK; PROTECTS; MTOR; PHOSPHORYLATION;

D O I：

10.1016/j.bbadis.2014.05.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Autophagy is an intracellular process responsible for damaged or unnecessary protein and organelle degradation. In the heart, autophagy occurs at basal level and dysregulated autophagy is associated with a variety of cardiovascular diseases. Autophagy is enhanced in ischemia as well as in the reperfusion phase during cardiac ischemia reperfusion (I/R) injury. More importantly, recent studies revealed that autophagy exerted both beneficial and detrimental effects in pathology of cardiac ischemia reperfusion. This paper is to review the functional significance of autophagy in cardiac ischemia reperfusion injury and discuss underlying signaling pathways. This article is part of a Special Issue entitled: Autophagy and protein quality control in cardiometabolic diseases. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：271 / 276

页数：6

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