Posttranscriptional control of mitochondrial biogenesis: Spatio-temporal regulation of the protein import process

被引：29

作者：

Devaux, Frederic ^{[1
]}

Lelandais, Gaelle ^{[3
]}

Garcia, Mathilde ^{[2
]}

Goussard, Sebastien ^{[2
]}

Jacq, Claude ^{[2
]}

机构：

[1] Univ Paris 06, Lab Genom Microorganismes, FRE3214, CNRS, F-75006 Paris, France

[2] Ecole Normale Super, Inst Biol, ENS, F-75005 Paris, France

[3] Univ Paris 07, INTS, Lab Dynam Struct & Interact Macromol Biol, INSERM,UMR S 665, F-75015 Paris, France

来源：

FEBS LETTERS | 2010年 / 584卷 / 20期

关键词：

RNA regulon; Mitochondria; TOR pathway; Post-genomics; CYTOCHROME-C-OXIDASE; RNA-BINDING PROTEIN; CHRONOLOGICAL LIFE-SPAN; INCREASED RESPIRATION; PRECURSOR PROTEINS; GENE-EXPRESSION; MESSENGER-RNAS; YEAST; TARGET; TOR;

D O I：

10.1016/j.febslet.2010.09.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review focuses on the posttranscriptional processes which govern mitochondrial biogenesis, with a special emphasis on the asymmetric localization-translation of nuclear-encoded mRNAs as an important regulatory step of the protein import process. We review how spatio-temporal mRNA regulons help to elicit timely, versatile, and coordinated intracellular processes to assemble mitochondrial structures. Our current knowledge on the mitochondrial import of respiratory chain assembly factors and the role of the ribonucleic acid (RNA) binding protein Puf3 are presented. A connection with the target of rapamycine signalling pathway may explain how respiratory chain assembly senses environmental conditions via the protein import machinery. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：4273 / 4279

页数：7

共 68 条

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