Chemoselective synthesis of novel aminoindolizines using aminopyridines, acetylenic diesters and α-halo ketones

被引：7

作者：

Asghari, Sakineh ^{[1
,2
]}

Qandalee, Mohammad ^{[3
]}

Behboodi, Vahideh ^{[1
]}

Gorji, Arastoo Nouri ^{[1
]}

Pasha, Ghasem Firouzzade ^{[1
]}

机构：

[1] Univ Mazandaran, Fac Chem, Dept Organ Chem, Babol Sar 4741695447, Iran

[2] Univ Mazandaran, Nano & Biotechnol Res Grp, Babol Sar 4741695447, Iran

[3] Islamic Azad Univ, Dept Biol, Garmsar Branch, Garmsar 4741656666, Iran

来源：

CHINESE CHEMICAL LETTERS | 2016年 / 27卷 / 03期

关键词：

Aminopyridines; alpha-Halo ketones; Acetylenic diesters; Indolizine; Chemoselective synthesis; DIASTEREOSELECTIVE SYNTHESIS; INDOLIZINE DERIVATIVES; EFFICIENT SYNTHESIS; N-HETEROCYCLES; SPIRO;

D O I：

10.1016/j.cclet.2015.11.007

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A chemoselective synthesis of novel indolizine derivatives were reported via three-component reactions of aminopyridines, acetylenic diesters and alpha-halo ketones. In these reactions, the zwitterion generated from aminopyridines and acetylenic diesters reacted with alpha-halo ketones to produce indolizine skeleton in good to high yields under mild reaction conditions. (C) 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

引用

页码：361 / 364

页数：4

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