Proof of concept for inhibiting metastasis: circulating tumor cell-triggered localized release of anticancer agent via a structure-switching aptamer

被引：15

作者：

Chen, Nandi ^{[1
]}

Yang, Xiaohai ^{[1
]}

Wang, Qing ^{[1
]}

Jian, Lixin ^{[1
]}

Shi, Hui ^{[1
]}

Qin, Shiya ^{[1
]}

Wang, Kemin ^{[1
]}

Huang, Jin ^{[1
]}

Liu, Wenjing ^{[1
]}

机构：

[1] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Key Lab Bionanotechnol & Mol Engn Hunan Prov, Changsha 410082, Hunan, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 41期

基金：

对外科技合作项目（国际科技项目）; 中国国家自然科学基金;

关键词：

CANCER THERAPEUTICS; TARGETED CANCER; NANOMEDICINE; CAPTURE;

D O I：

10.1039/c6cc02374f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Existing drug delivery systems were not suitable for killing cells in the circulatory system specifically. Herein, we developed a novel localized drug delivery strategy, in which the release of anticancer agents was specifically triggered by circulating tumor cells. Meanwhile, damage to non-target cells was avoided.

引用

页码：6789 / 6792

页数：4

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