Molecular pathogenesis of neuroinflammation

被引：39
作者：
Bradl, M [1 ]
Hohlfeld, R [1 ]
机构：
[1] Dept Neuroimmunol, Inst Brain Res, A-1090 Vienna, Austria
来源：
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 2003年 / 74卷 / 10期
关键词：
D O I：
10.1136/jnnp.74.10.1364
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The past few years have seen significant progress towards understanding the mechanisms of immune surveillance and inflammation in the nervous system. In this review, the milestones of scientific discovery in this field are discussed, and the strengths and limitations of the different ways of examining the molecular pathogenesis of neuroinflammation examined. The review is limited to the inflammatory reactions of the central nervous system that occur in multiple sclerosis and experimental autoimmune encephalomyelitis.
引用
收藏
页码：1364 / 1370
页数：7
相关论文
共 72 条
  • [31] Epitope spreading is not required for relapses in experimental autoimmune encephalomyelitis
    Jones, RE
    Bourdette, D
    Moes, N
    Vandenbark, A
    Zamora, A
    Offner, H
    [J]. JOURNAL OF IMMUNOLOGY, 2003, 170 (04) : 1690 - 1698
  • [32] KABAT EA, 1947, J EXP MED, V85, P117, DOI 10.1084/jem.85.1.117
  • [33] GLIAL-CELL DEGENERATION AND HYPOMYELINATION CAUSED BY OVEREXPRESSION OF MYELIN PROTEOLIPID PROTEIN GENE
    KAGAWA, T
    IKENAKA, K
    INOUE, Y
    KURIYAMA, S
    TSUJII, T
    NAKAO, J
    NAKAJIMA, K
    ARUGA, J
    OKANO, H
    MIKOSHIBA, K
    [J]. NEURON, 1994, 13 (02) : 427 - 442
  • [34] Neurotrophic cross-talk between the nervous and immune systems: Implications for neurological diseases
    Kerschensteiner, M
    Stadelmann, C
    Dechant, G
    Wekerle, H
    Hohlfeld, R
    [J]. ANNALS OF NEUROLOGY, 2003, 53 (03) : 292 - 304
  • [35] Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: A neuroprotective role of inflammation?
    Kerschensteiner, M
    Gallmeier, E
    Behrens, L
    Leal, VV
    Misgeld, T
    Klinkert, WEF
    Kolbeck, R
    Hoppe, E
    Oropeza-Wekerle, RL
    Bartke, I
    Stadelmann, C
    Lassmann, H
    Wekerle, H
    Hohlfeld, R
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (05) : 865 - 870
  • [36] EXPERIMENTAL AUTOIMMUNE PANENCEPHALITIS AND UVEORETINITIS TRANSFERRED TO THE LEWIS RAT BY T-LYMPHOCYTES SPECIFIC FOR THE S100-BETA MOLECULE, A CALCIUM-BINDING PROTEIN OF ASTROGLIA
    KOJIMA, K
    BERGER, T
    LASSMANN, H
    HINZESELCH, D
    ZHANG, YP
    GEHRMANN, J
    RESKE, K
    WEKERLE, H
    LININGTON, C
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (03) : 817 - 829
  • [37] Kornek B, 1999, BRAIN PATHOL, V9, P651
  • [38] GENE-TRANSFER THROUGH THE BLOOD-NERVE BARRIER - NGF-ENGINEERED NEURITOGENIC T-LYMPHOCYTES ATTENUATE EXPERIMENTAL AUTOIMMUNE NEURITIS
    KRAMER, R
    ZHANG, YP
    GEHRMANN, J
    GOLD, R
    THOENEN, H
    WEKERLE, H
    [J]. NATURE MEDICINE, 1995, 1 (11) : 1162 - 1166
  • [39] A functional and structural basis for TCR cross-reactivity in multiple sclerosis
    Lang, HLE
    Jacobsen, H
    Ikemizu, S
    Andersson, C
    Harlos, K
    Madsen, L
    Hjorth, P
    Sondergaard, L
    Svejgaard, A
    Wucherpfennig, K
    Stuart, DI
    Bell, JI
    Jones, EY
    Fugger, L
    [J]. NATURE IMMUNOLOGY, 2002, 3 (10) : 940 - 943
  • [40] LININGTON C, 1988, AM J PATHOL, V130, P443
12345678