Nanoengineered Surfaces Enhance Drug Loading and Adhesion

被引：27

作者：

Fischer, Kathleen E. ^{[1
,2
]}

Jayagopal, Aishwarya ^{[1
]}

Nagaraj, Ganesh ^{[1
]}

Danies, R. Hugh ^{[3
]}

Li, Esther M. ^{[3
]}

Silvestrini, Matthew T. ^{[1
]}

Desai, Tejal A. ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, UCB, Joint Grad Grp Bioengn, San Francisco, CA 94158 USA

[3] Nanosys Inc, Palo Alto, CA 94304 USA

来源：

NANO LETTERS | 2011年 / 11卷 / 03期

关键词：

Nanowires; adhesion; drug delivery; hierarchical nanostructures; MESOPOROUS SILICON; DELIVERY-SYSTEM; POROUS SILICON; ORAL DELIVERY; PARTICLES; MUCUS;

D O I：

10.1021/nl103951e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

To circumvent the barriers encountered by macromolecules at the gastrointestinal mucosa, sufficient therapeutic macromolecules must be delivered in close proximity to cells.(1) Previously, we have shown that silicon nanowires penetrate the mucous layer and adhere directly to cells under high shear.(2) In this work, we characterize potential reservoirs and load macromolecules into interstitial space between nanowires. We show significant increases in loading capacity due to nanowires while retaining adhesion of loaded particles under high shear.

引用

页码：1076 / 1081

页数：6

共 25 条

[1] Porous silicon in drug delivery devices and materials [J].

Anglin, Emily J. ;

Cheng, Lingyun ;

Freeman, William R. ;

Sailor, Michael J. .

ADVANCED DRUG DELIVERY REVIEWS, 2008, 60 (11) :1266-1277

[2] Lectin-mediated drug targeting: history and applications [J].

Bies, C ;

Lehr, CM ;

Woodley, JF .

ADVANCED DRUG DELIVERY REVIEWS, 2004, 56 (04) :425-435

[3] HUMAN GASTRIC-EMPTYING AND COLONIC FILLING OF SOLIDS CHARACTERIZED BY A NEW METHOD [J].

CAMILLERI, M ;

COLEMONT, LJ ;

PHILLIPS, SF ;

BROWN, ML ;

THOMFORDE, GM ;

CHAPMAN, N ;

ZINSMEISTER, AR .

AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 257 (02) :G284-G290

[4] Barrier properties of mucus [J].

Cone, Richard A. .

ADVANCED DRUG DELIVERY REVIEWS, 2009, 61 (02) :75-85

[5] Variability of gastrointestinal transit in healthy women and men [J].

Degen, LP ;

Phillips, SF .

GUT, 1996, 39 (02) :299-305

[6]

DESAI T, 2010, NANO STRUCTURE BASED

[7] Possibility of a patch system as a new oral delivery system [J].

Eaimtrakarn, S ;

Prasad, YVR ;

Puthli, SP ;

Yoshikawa, Y ;

Shibata, N ;

Takada, K .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2003, 250 (01) :111-117

[8] Biomimetic Nanowire Coatings for Next Generation Adhesive Drug Delivery Systems [J].

Fischer, Kathleen E. ;

Aleman, Benjamin J. ;

Tao, Sarah L. ;

Daniels, R. Hugh ;

Li, Esther M. ;

Buenger, Mark D. ;

Nagaraj, Ganesh ;

Singh, Parminder ;

Zettl, Alex ;

Desai, Tejal A. .

NANO LETTERS, 2009, 9 (02) :716-720

[9]

FISCHER KE, 2011, BIOMATERIAL IN PRESS

[10] Microfabricated porous silicon particles enhance paracellular delivery of insulin across intestinal Caco-2 cell monolayers [J].

Foraker, AB ;

Walczak, RJ ;

Cohen, MH ;

Boiarski, TA ;

Grove, CF ;

Swaan, PW .

PHARMACEUTICAL RESEARCH, 2003, 20 (01) :110-116

← 1 2 3 →