Nanoengineered Surfaces Enhance Drug Loading and Adhesion

被引：27

作者：

Fischer, Kathleen E. ^{[1
,2
]}

Jayagopal, Aishwarya ^{[1
]}

Nagaraj, Ganesh ^{[1
]}

Danies, R. Hugh ^{[3
]}

Li, Esther M. ^{[3
]}

Silvestrini, Matthew T. ^{[1
]}

Desai, Tejal A. ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, UCB, Joint Grad Grp Bioengn, San Francisco, CA 94158 USA

[3] Nanosys Inc, Palo Alto, CA 94304 USA

来源：

NANO LETTERS | 2011年 / 11卷 / 03期

关键词：

Nanowires; adhesion; drug delivery; hierarchical nanostructures; MESOPOROUS SILICON; DELIVERY-SYSTEM; POROUS SILICON; ORAL DELIVERY; PARTICLES; MUCUS;

D O I：

10.1021/nl103951e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

To circumvent the barriers encountered by macromolecules at the gastrointestinal mucosa, sufficient therapeutic macromolecules must be delivered in close proximity to cells.(1) Previously, we have shown that silicon nanowires penetrate the mucous layer and adhere directly to cells under high shear.(2) In this work, we characterize potential reservoirs and load macromolecules into interstitial space between nanowires. We show significant increases in loading capacity due to nanowires while retaining adhesion of loaded particles under high shear.

引用

页码：1076 / 1081

页数：6

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